Comparison of Thiel-fixed and fresh-frozen temporal bon biomechanics with dynamic synchrotron-based X-ray imaging.
Details
State: Public
Version: Final published version
License: CC BY-NC 4.0
Serval ID
serval:BIB_31403E3E1618
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Comparison of Thiel-fixed and fresh-frozen temporal bon biomechanics with dynamic synchrotron-based X-ray imaging.
Journal
Clinical biomechanics
ISSN
1879-1271 (Electronic)
ISSN-L
0268-0033
Publication state
Published
Issued date
05/2025
Peer-reviewed
Oui
Volume
125
Pages
106522
Language
english
Notes
Publication types: Journal Article ; Comparative Study
Publication Status: ppublish
Publication Status: ppublish
Abstract
The Thiel embalming method offers lifelike tissue preservation, yet its suitability for biomechanical studies remains debated.
Here, we investigated two human temporal bones, one Thiel-fixed and one fresh-frozen, using dynamic synchrotron-based X-ray imaging under acoustic stimulation.
Both specimens exhibited a linear response at the umbo, but the Thiel-fixed specimen displayed discontinuity after the incudo-malleolar joint, suggesting ossicular chain stiffening. Our findings align well with previous studies indicating potential tissue degradation induced by Thiel-embalming.
These observations question the use of Thiel-fixed human specimens for biomechanical measurements on the middle ear, especially using dynamic synchrotron-based X-ray imaging. They emphasize the need for further assessment of the impact of Thiel-embalming methods on tissue mechanics.
Here, we investigated two human temporal bones, one Thiel-fixed and one fresh-frozen, using dynamic synchrotron-based X-ray imaging under acoustic stimulation.
Both specimens exhibited a linear response at the umbo, but the Thiel-fixed specimen displayed discontinuity after the incudo-malleolar joint, suggesting ossicular chain stiffening. Our findings align well with previous studies indicating potential tissue degradation induced by Thiel-embalming.
These observations question the use of Thiel-fixed human specimens for biomechanical measurements on the middle ear, especially using dynamic synchrotron-based X-ray imaging. They emphasize the need for further assessment of the impact of Thiel-embalming methods on tissue mechanics.
Keywords
Humans, Synchrotrons, Temporal Bone/diagnostic imaging, Temporal Bone/physiology, Biomechanical Phenomena, Embalming/methods, Freezing, X-Rays, Ear, Middle/diagnostic imaging, Ear, Middle/physiology, 3D visualization, Dynamic microtomography, Hearing Ossicles, Human middle ear, Phase-contrast, Synchrotron-based X-ray, Time-resolved experiments, Tissue fixation
Pubmed
Web of science
Open Access
Yes
Create date
17/04/2025 15:34
Last modification date
13/05/2025 7:14
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