Differentiation of Crystals Associated With Arthropathies by Spectral Photon-Counting Radiography: A Proof-of-Concept Study.

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State: Public
Version: Final published version
License: All rights reserved
Serval ID
serval:BIB_3139582D7BF5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Differentiation of Crystals Associated With Arthropathies by Spectral Photon-Counting Radiography: A Proof-of-Concept Study.
Journal
Investigative radiology
Author(s)
Huber F.A., Becce F., Gkoumas S., Thüring T., Steinmetz S., Letovanec I., Guggenberger R.
ISSN
1536-0210 (Electronic)
ISSN-L
0020-9996
Publication state
Published
Issued date
01/03/2021
Peer-reviewed
Oui
Volume
56
Number
3
Pages
147-152
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The aims of this study were to test whether spectral photon-counting radiography (SPCR) is able to identify and distinguish different crystals associated with arthropathies in vitro and to validate findings in a gouty human third toe ex vivo.
Industry-standard calibration rods of calcium pyrophosphate, calcium hydroxyapatite (HA), and monosodium urate (MSU) were scanned with SPCR in an experimental setup. Each material was available at 3 different concentrations, and a dedicated photon-counting detector was used for SPCR, whereas validation scans were obtained on a clinical dual-energy computed tomography (DECT) scanner. Regions of interest were placed on SPCR images and consecutive DECT images to measure x-ray attenuation characteristics, including effective atomic numbers (Zeff). Statistical tests were performed for differentiation of Zeff between concentrations, materials, and imaging modalities. In addition, a third toe from a patient with chronic gouty arthritis was scanned with SPCR and DECT for differentiation of MSU from HA.
In both SPCR and DECT, significant differences in attenuation and Zeff values were found for different concentrations among (P < 0.001) and between different materials (P < 0.001). Overall, quantitative measurements of Zeff did not differ significantly between SPCR- and DECT-derived measurements (P = 0.054-0.412). In the human cadaver toe, gouty bone erosions were visible on standard grayscale radiographic images; however, spectral image decomposition revealed the nature and extent of MSU deposits and was able to separate it from bone HA by Zeff.
Identification and differentiation of different crystals related to arthropathies are possible with SPCR at comparable diagnostic accuracy to DECT. Further research is needed to assess diagnostic accuracy and clinical usability in vivo.
Pubmed
Web of science
Open Access
Yes
Create date
31/08/2020 10:40
Last modification date
27/03/2021 6:32
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