Seroprevalence of HBV (anti-HBc, HBsAg and anti-HBs) and HDV infections among 9006 women at delivery

Details

Serval ID
serval:BIB_311D43250D27
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Seroprevalence of HBV (anti-HBc, HBsAg and anti-HBs) and HDV infections among 9006 women at delivery
Journal
Liver
Author(s)
Bart  P. A., Jacquier  P., Zuber  P. L., Lavanchy  D., Frei  P. C.
ISSN
0106-9543 (Print)
Publication state
Published
Issued date
04/1996
Volume
16
Number
2
Pages
110-6
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Apr
Abstract
Serum samples from 9006 women, who delivered in Switzerland in 1990 and 1991, were collected around the country. Of these women, 62.7% were Swiss and 37.3% originated from foreign countries. Samples were first screened for anti-HBc and those found positive were further tested for HBsAg, anti-HBs and anti-HDV. Anti-HBc was found in 640 of the 9006 women (overall prevalence, 7.1%; Swiss, 3.3%; foreigners, 13.5%). Of these 640 positive samples, 61 (9.5%) were positive for HBsAg (without anti-HBs), 467 (73.0%) positive for anti-HBs (without HBsAg) and 8 (1.3%) positive for both HBsAg and anti-HBs. The remaining 104 were thus anti-HBc positive without HBsAg or anti-HBs. These 104 specimens with the so-called "isolated anti-HBc" reactivity represented 1.2% of the whole population or 16.3% of the 640 anti-HBc positive mothers. All were HBV DNA negative (PCR). Anti-HDV antibody was found in only five women. HBsAg was seen in 38 of the cord-blood samples from the anti-HBc positive mothers. In this large sampling, we observed a relatively high seroprevalence of HBV infection. Cases with isolated anti-HBc reactivity, being HBV DNA negative by PCR, were probably non-infectious at the time of blood collection.
Keywords
Base Sequence DNA, Viral/blood Female Fetal Blood/immunology/virology Hepatitis Antibodies/*blood Hepatitis B/*epidemiology/*immunology Hepatitis B Antibodies/*blood Hepatitis B Core Antigens/*blood Hepatitis B Surface Antigens/*blood Hepatitis D/epidemiology/*immunology Hepatitis Delta Virus/*immunology Humans Infant, Newborn Molecular Sequence Data Polymerase Chain Reaction Pregnancy Pregnancy Complications, Infectious/*immunology Switzerland/epidemiology
Pubmed
Web of science
Create date
25/01/2008 14:49
Last modification date
20/08/2019 13:16
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