Myeloid-Derived Suppressor Cells in Sepsis.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_31178C23B5D8
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Myeloid-Derived Suppressor Cells in Sepsis.
Journal
Frontiers in immunology
Author(s)
Schrijver I.T., Théroude C., Roger T.
ISSN
1664-3224 (Electronic)
ISSN-L
1664-3224
Publication state
Published
Issued date
2019
Peer-reviewed
Oui
Volume
10
Pages
327
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: epublish
Abstract
Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells characterized by their immunosuppressive functions. MDSCs expand during chronic and acute inflammatory conditions, the best described being cancer. Recent studies uncovered an important role of MDSCs in the pathogenesis of infectious diseases along with sepsis. Here we discuss the mechanisms underlying the expansion and immunosuppressive functions of MDSCs, and the results of preclinical and clinical studies linking MDSCs to sepsis pathogenesis. Strikingly, all clinical studies to date suggest that high proportions of blood MDSCs are associated with clinical worsening, the incidence of nosocomial infections and/or mortality. Hence, MDSCs are attractive biomarkers and therapeutic targets for sepsis, especially because these cells are barely detectable in healthy subjects. Blocking MDSC-mediated immunosuppression and trafficking or depleting MDSCs might all improve sepsis outcome. While some key aspects of MDSCs biology need in depth investigations, exploring these avenues may participate to pave the way toward the implementation of personalized medicine and precision immunotherapy for patients suffering from sepsis.
Keywords
Biomarkers, Disease Susceptibility, Granulocytes/immunology, Granulocytes/metabolism, Host-Pathogen Interactions/immunology, Humans, Immune Tolerance, Immunity, Innate, Immunomodulation, Myeloid-Derived Suppressor Cells/immunology, Myeloid-Derived Suppressor Cells/metabolism, Prognosis, Sepsis/diagnosis, Sepsis/etiology, Sepsis/metabolism, Sepsis/mortality, biomarker, immunosuppression, infectious disease, inflammation, innate immunity, myeloid-derived suppressor cells, personalized medicine, sepsis
Pubmed
Web of science
Open Access
Yes
Create date
17/03/2019 16:53
Last modification date
25/07/2020 5:19
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