Oxidative folding of proteins

Details

Serval ID
serval:BIB_30ED6998DF9D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Oxidative folding of proteins
Journal
Acc Chem Res
Author(s)
Narayan  M., Welker  E., Wedemeyer  W. J., Scheraga  H. A.
ISSN
0001-4842 (Print)
Publication state
Published
Issued date
11/2000
Volume
33
Number
11
Pages
805-12
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Nov
Abstract
The oxidative folding of proteins is reviewed and illustrated with bovine pancreatic ribonuclease A (RNase A). The mutual effects of conformational folding and disulfide bond regeneration are emphasized, particularly the "locking in" of native disulfide bonds by stable tertiary structure in disulfide intermediates. Two types of structured metastable disulfide species are discerned, depending on the relative protection of their disulfide bonds and thiol groups. Four generic pathways for oxidative folding are identified and characterized.
Keywords
Animals Cattle Disulfides/chemistry Oxidation-Reduction *Protein Folding Ribonuclease, Pancreatic/chemistry
Pubmed
Web of science
Create date
24/01/2008 14:40
Last modification date
20/08/2019 13:15
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