A-kinase-anchoring protein-Lbc anchors IκB kinase β to support interleukin-6-mediated cardiomyocyte hypertrophy.

Details

Serval ID
serval:BIB_30B6BD34FAC4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A-kinase-anchoring protein-Lbc anchors IκB kinase β to support interleukin-6-mediated cardiomyocyte hypertrophy.
Journal
Molecular and Cellular Biology
Author(s)
del Vescovo C.D., Cotecchia S., Diviani D.
ISSN
1098-5549 (Electronic)
ISSN-L
0270-7306
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
33
Number
1
Pages
14-27
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Abstract
In response to stress, the heart undergoes a pathological remodeling process associated with hypertrophy and the reexpression of a fetal gene program that ultimately causes cardiac dysfunction and heart failure. In this study, we show that A-kinase-anchoring protein (AKAP)-Lbc and the inhibitor of NF-κB kinase subunit β (IKKβ) form a transduction complex in cardiomyocytes that controls the production of proinflammatory cytokines mediating cardiomyocyte hypertrophy. In particular, we can show that activation of IKKβ within the AKAP-Lbc complex promotes NF-κB-dependent production of interleukin-6 (IL-6), which in turn enhances fetal gene expression and cardiomyocyte growth. These findings provide a new mechanistic hypothesis explaining how hypertrophic signals are coordinated and conveyed to interleukin-mediated transcriptional reprogramming events in cardiomyocytes.
Pubmed
Web of science
Open Access
Yes
Create date
22/11/2012 10:36
Last modification date
20/08/2019 14:15
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