Current State of Compassionate Phage Therapy.

Details

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_30AAF2E954D2
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Current State of Compassionate Phage Therapy.
Journal
Viruses
Author(s)
McCallin S., Sacher J.C., Zheng J., Chan B.K.
ISSN
1999-4915 (Electronic)
ISSN-L
1999-4915
Publication state
Published
Issued date
12/04/2019
Peer-reviewed
Oui
Volume
11
Number
4
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: epublish
Abstract
There is a current unmet medical need for the treatment of antibiotic-resistant infections, and in the absence of approved alternatives, some clinicians are turning to empirical ones, such as phage therapy, for compassionate treatment. Phage therapy is ideal for compassionate use due to its long-standing historical use and publications, apparent lack of adverse effects, and solid support by fundamental research. Increased media coverage and peer-reviewed articles have given rise to a more widespread familiarity with its therapeutic potential. However, compassionate phage therapy (cPT) remains limited to a small number of experimental treatment centers or associated with individual physicians and researchers. It is possible, with the creation of guidelines and a greater central coordination, that cPT could reach more of those in need, starting by increasing the availability of phages. Subsequent steps, particularly production and purification, are difficult to scale, and treatment paradigms stand highly variable between cases, or are frequently not reported. This article serves both to synopsize cPT publications to date and to discuss currently available phage sources for cPT. As the antibiotic resistance crisis continues to grow and the future of phage therapy clinical trials remains undetermined, cPT represents a possibility for bridging the gap between current treatment failures and future approved alternatives. Streamlining the process of cPT will help to ensure high quality, therapeutically-beneficial, and safe treatment.
Keywords
Bacterial Infections/therapy, Compassionate Use Trials, Drug Resistance, Multiple, Bacterial, Humans, Phage Therapy, antibiotic resistance, bacteriophage therapy, compassionate use
Pubmed
Web of science
Open Access
Yes
Create date
03/05/2019 17:12
Last modification date
21/02/2020 7:19
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