The relative risk of second primary cancers in Switzerland: a population-based retrospective cohort study.

Details

Serval ID
serval:BIB_309F3E21A26F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The relative risk of second primary cancers in Switzerland: a population-based retrospective cohort study.
Journal
BMC cancer
Author(s)
Feller A., Matthes K.L., Bordoni A., Bouchardy C., Bulliard J.L., Herrmann C., Konzelmann I., Maspoli M., Mousavi M., Rohrmann S., Staehelin K., Arndt V., Staehelin K., Bouchardy C., Mousavi M., Bulliard J.L., Maspoli M., Mousavi M., Bordoni A., Konzelmann I., Blanc-Moya R., Rohrmann S.
Working group(s)
NICER Working Group
ISSN
1471-2407 (Electronic)
ISSN-L
1471-2407
Publication state
Published
Issued date
21/01/2020
Peer-reviewed
Oui
Volume
20
Number
1
Pages
51
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
More people than ever before are currently living with a diagnosis of cancer and the number of people concerned is likely to continue to rise. Cancer survivors are at risk of developing a second primary cancer (SPC). This study aims to investigate the risk of SPC in Switzerland.
The study cohort included all patients with a first primary cancer recorded in 9 Swiss population-based cancer registries 1981-2009 who had a minimum survival of 6 months, and a potential follow-up until the end of 2014. We calculated standardized incidence ratios (SIR) to estimate relative risks (RR) of SPC in cancer survivors compared with the cancer risk of the general population. SIR were stratified by type of first cancer, sex, age and period of first diagnosis, survival period and site of SPC.
A total of 33,793 SPC were observed in 310,113 cancer patients. Both male (SIR 1.18, 95%CI 1.16-1.19) and female (SIR 1.20, 95%CI 1.18-1.22) cancer survivors had an elevated risk of developing a SPC. Risk estimates varied substantially according to type of first cancer and were highest in patients initially diagnosed with cancer of the oral cavity and pharynx, Hodgkin lymphoma, laryngeal, oesophageal, or lung cancer. Age-stratified analyses revealed a tendency towards higher RR in patients first diagnosed at younger ages. Stratified by survival period, risk estimates showed a rising trend with increasing time from the initial diagnosis. We observed strong associations between particular types of first and SPC, i.e. cancer types sharing common risk factors such as smoking or alcohol consumption (e.g. repeated cancer of the oral cavity and pharynx (SIR <sub>males</sub> 20.12, 95%CI 17.91-22.33; SIR <sub>females</sub> 37.87, 95%CI 30.27-45.48).
Swiss cancer survivors have an increased risk of developing a SPC compared to the general population, particularly patients first diagnosed before age 50 and those surviving more than 10 years. Cancer patients should remain under continued surveillance not only for recurrent cancers but also for new cancers. Some first and SPCs share lifestyle associated risk factors making it important to promote healthier lifestyles in both the general population and cancer survivors.
Keywords
Cohort study, Relative risk, Retrospective, Second primary cancer, Switzerland
Pubmed
Web of science
Open Access
Yes
Create date
23/01/2020 15:48
Last modification date
17/07/2020 6:26
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