Direct in vivo measurement of human cerebral GABA concentration using MEGA-editing at 7 Tesla.

Details

Serval ID
serval:BIB_30969835796B
Type
Article: article from journal or magazin.
Collection
Publications
Title
Direct in vivo measurement of human cerebral GABA concentration using MEGA-editing at 7 Tesla.
Journal
Magnetic Resonance in Medicine
Author(s)
Terpstra M., Ugurbil K., Gruetter R.
ISSN
0740-3194 (Print)
ISSN-L
0740-3194
Publication state
Published
Issued date
2002
Volume
47
Number
5
Pages
1009-1012
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.Publication Status: ppublish
Abstract
Spectral editing of the GABA spin system is hampered by coediting of macromolecule (MM) coherences. To reduce contamination arising from MMs in spectra edited for GABA, the highest field strength currently available for human experimentation (7 Tesla) and MEGA-based editing were used. Despite judicious choice of experimental parameters, MM contamination was found to arise from field drifts. When the MM contribution was accounted for, [GABA] = 0.75 +/- 0.14 micromol/g (mean +/- SD, N = 16) relative to 8 micromol/g creatine (Cr), whereas without accounting for the MM signal [GABA*] = 0.88 +/- 0.23 micromol/g (mean +/- SD, N = 16). Incorporating the direct experimental assessment of MM contamination to the edited GABA signal substantially reduced the variance of the measurement, resulting in concentrations that were in excellent agreement with previous (13)C labeling experiments.
Keywords
Adult, Brain Chemistry, Female, Humans, Macromolecular Substances, Magnetic Resonance Spectroscopy/methods, Male, gamma-Aminobutyric Acid/analysis
Pubmed
Web of science
Open Access
Yes
Create date
04/08/2010 15:28
Last modification date
20/08/2019 13:15
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