GPR40 mediates potential positive effects of a saturated fatty acid enriched diet on bone.

Details

Serval ID
serval:BIB_306588060812
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
GPR40 mediates potential positive effects of a saturated fatty acid enriched diet on bone.
Journal
Molecular nutrition & food research
Author(s)
Philippe C., Wauquier F., Landrier J.F., Bonnet L., Miot-Noirault E., Rochefort G.Y., Sadoine J., Asrih M., Jornayvaz F.R., Bernalier A., Coxam V., Wittrant Y.
ISSN
1613-4133 (Electronic)
ISSN-L
1613-4125
Publication state
Published
Issued date
02/2017
Peer-reviewed
Oui
Volume
61
Number
2
Pages
10
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The stimulation of the free fatty acid receptor G-protein coupled receptor (GPR) 40 by GW9508 prevents bone loss by inhibiting osteoclast activity, both in vitro and in vivo. Here, we questioned whether the stimulation of the GPR40 receptor by dietary fatty acids may lead to the same beneficial effect on bone.
We investigated (i) the impact of a fatty acid enriched diet (high-fat diet [HFD]) on bone health in C57/BL6 female mice depending on (ii) the estrogen status (ovariectomy) and (iii) the genotype (GPR40+/+ or GPR40-/- ). Bone mineral density (BMD), body composition, weight, inflammation and bone remodeling parameters were monitored. HFD decreased BMD in HFD-SH-GPR40+/+ mice but OVX failed to further impact BMD in HFD-OVX-GPR40+/+ mice, while additional bone loss was observed in HFD-OVX-GPR40-/- animals. These data suggest that when stimulated by fatty acid enriched diets GPR40 contributes to counteract ovariectomy-induced bone alteration. The sparing effect is supported by the modulation of both the osteoprotegerin/receptor activator of nuclear factor kappa-B ligand (OPG/RANKL) ratio in blood stream and the expression level of inflammatory markers in adipose tissues. Bone preservation by GPR40 stimulation is dependent on the presence of long-chain saturated fatty acids.
GPR40 contributes to counter ovariectomy-induced bone loss in a context of saturated fatty acid enrichment.

Keywords
Animals, Bone Density/drug effects, Diet, High-Fat/adverse effects, Disease Models, Animal, Fatty Acids/pharmacology, Female, Methylamines/pharmacology, Mice, Inbred C57BL, Mice, Mutant Strains, Osteoporosis/diet therapy, Osteoporosis/etiology, Osteoporosis/prevention & control, Ovariectomy/adverse effects, Panniculitis/etiology, Panniculitis/pathology, Propionates/pharmacology, RANK Ligand/metabolism, Receptors, G-Protein-Coupled/genetics, Receptors, G-Protein-Coupled/metabolism, Free fatty acid receptor, GPR40, High-fat diet, Nutrition, Osteoporosis
Pubmed
Web of science
Create date
13/09/2016 13:30
Last modification date
20/08/2019 13:15
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