Effet de l'huile d'argan sur la fonction cardiaque au cours de l'ischemie et de la reperfusion. [The effect of argan oil on heart function during ischemia and reperfusion]

Details

Serval ID
serval:BIB_302C422C299B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effet de l'huile d'argan sur la fonction cardiaque au cours de l'ischemie et de la reperfusion. [The effect of argan oil on heart function during ischemia and reperfusion]
Journal
Thérapie
Author(s)
Benajiba  N., Morel  S., De Leiris  J., Boucher  F., Charrouf  Z., Mokhtar  N., Aguenaou  H.
ISSN
0040-5957 (Print)
Publication state
Published
Issued date
06/2002
Volume
57
Number
3
Pages
246-52
Notes
English Abstract
In Vitro
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May-Jun
Abstract
The aim of this study was to evaluate the effect of organ oil on isolated heart function before and after ischemia and on the activity of cardiac antioxidant enzymes. 16 Wistar rats were divided into 2 groups; control group and treated group receiving 5 mL/kg/day of organ oil. After 8 weeks of treatment, hearts were perfused and subjected to a global ischemia followed by reperfusion. Activity of cardiac antioxidant enzymes was assessed in freeze-clamped hearts at the end of reperfusion. Results showed that organ oil induces: 1--damage to heart function during the preischemic period, 2--decreased functional recovery during reperfusion and 3--significant increase in catalase activity. It seems that, in our experimental conditions, organ oil increases heart sensitivity to ischemia and reperfusion. However, the mechanism involved has yet to be understood.
Keywords
Animals Antioxidants/metabolism Heart/*drug effects Male Myocardium/enzymology Plant Oils/*pharmacology Rats Rats, Wistar Reperfusion Injury/*physiopathology Sapotaceae/*chemistry
Pubmed
Web of science
Create date
28/01/2008 9:36
Last modification date
20/08/2019 13:14
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