The contribution of three strong candidate schizophrenia susceptibility genes in demographically distinct populations.
Details
Serval ID
serval:BIB_301BA1B0C008
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The contribution of three strong candidate schizophrenia susceptibility genes in demographically distinct populations.
Journal
Genes, Brain, and Behavior
ISSN
1601-1848 (Print)
ISSN-L
1601-183X
Publication state
Published
Issued date
2004
Volume
3
Number
4
Pages
240-248
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Publication Status: ppublish
Abstract
Here we characterize and compare the contribution of three recently identified strong candidate schizophrenia susceptibility genes; G72, neuregulin 1 (NRG1) and dystrobrevin-binding protein 1 (DTNBP1) in two independent datasets of patients with distinct genetic backgrounds. On the basis of corrected P-values from single- and multilocus transmission distortion tests our analysis provides no support for a contribution of G72, NRG1 or DTNBP1 in the tested samples. When transmission of individual haplotypes was considered, a picture more consistent with the original studies emerged, where transmission distortions in the same direction as the original samples and involving the same core haplotypes were observed for G72 and NRG1. Interestingly, whereas the NRG1 gene analysis was dominated by the presence of over-transmitted haplotypes, the G72 gene analysis was consistently dominated in both datasets by under-transmissions. Negative transmissions involved a core haplotype complementary to the originally detected over-transmitted haplotype, suggesting the presence of a protective variant within the G72 locus.
Keywords
Carrier Proteins/genetics, Genetic Predisposition to Disease, Genetic Variation, Humans, Neuregulin-1/genetics, Pedigree, Schizophrenia/epidemiology, Schizophrenia/genetics, South Africa/epidemiology, United States/epidemiology
Pubmed
Open Access
Yes
Create date
27/02/2012 17:23
Last modification date
20/08/2019 14:14