Early Antimicrobial Therapy for Sepsis: Does Each Hour Really Count?

Details

Serval ID
serval:BIB_2FF40F08C5BA
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Early Antimicrobial Therapy for Sepsis: Does Each Hour Really Count?
Journal
Seminars in respiratory and critical care medicine
Author(s)
Guery B., Calandra T.
ISSN
1098-9048 (Electronic)
ISSN-L
1069-3424
Publication state
Published
Issued date
08/2019
Peer-reviewed
Oui
Volume
40
Number
4
Pages
447-453
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
For the last decades, the timing of antimicrobial therapy has remained a hotly debated topic in sepsis as well as other infectious diseases like community-acquired pneumonia (CAP) or bacterial meningitis (CABM). In CAP, a relationship between the time to antibiotic administration and mortality was found only in the largest cohort, but all these studies were retrospective and of low quality. In CABM, the level of evidence remains also limited, but there is now a good body of evidence linking the delay to antibiotic administration to unfavorable outcome. The European guidelines strongly suggest that time period should not exceed 1 hour. Finally, in sepsis, if the 1-hour cut-off remains debatable for sepsis patients, early administration (within 3 hours) is recommended in sepsis and sepsis shock as suggested by the surviving sepsis campaign recommendations. To conclude, all these data are in favor of a potential link between the time to antibiotic administration and survival, but we still miss randomized controlled studies to give a definite answer.
Keywords
Anti-Bacterial Agents/therapeutic use, Community-Acquired Infections/drug therapy, Community-Acquired Infections/mortality, Humans, Meningitis/drug therapy, Meningitis/mortality, Patient Admission/statistics & numerical data, Practice Guidelines as Topic, Sepsis/drug therapy, Sepsis/mortality, Time Factors
Pubmed
Web of science
Create date
08/10/2019 21:03
Last modification date
03/05/2020 6:02
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