Mental stress induces prolonged endothelial dysfunction via endothelin-A receptors

Details

Serval ID
serval:BIB_2FEF80844A44
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Mental stress induces prolonged endothelial dysfunction via endothelin-A receptors
Journal
Circulation
Author(s)
Spieker  L. E., Hurlimann  D., Ruschitzka  F., Corti  R., Enseleit  F., Shaw  S., Hayoz  D., Deanfield  J. E., Luscher  T. F., Noll  G.
ISSN
1524-4539 (Electronic)
Publication state
Published
Issued date
06/2002
Volume
105
Number
24
Pages
2817-20
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun 18
Abstract
BACKGROUND: Mental stress is a risk factor for atherosclerosis and may precipitate myocardial ischemia and infarction. Because endothelial dysfunction is an early manifestation of atherosclerosis, we investigated the impact of mental stress on endothelial function. Methods and Results- The effects of a 3-minute mental stress task on endothelium-dependent vasodilation were studied in healthy subjects without cardiovascular risk factors. Flow-mediated (FMD) and nitroglycerin (0.4 mg sublingual)-induced vasodilation were studied before and after mental stress by high-resolution ultrasound of the radial artery. Additionally, FMD was assessed before and 10 to 45 minutes after mental stress during intraarterial infusion of a selective endothelin A receptor antagonist (BQ-123, 1 nmol/min) or saline, respectively. Endothelium-dependent vasodilation was reduced by half for about 45 minutes (8.0+/-1.1% versus 4.1+/-1.0%; P<0.002), whereas endothelium-independent vasodilation to nitroglycerin remained unaffected (15.6+/-1.6 versus 14.3+/-1.3%; NS). Intraarterial infusion of BQ-123, a selective endothelin-A receptor antagonist, but not saline prevented the impairment of endothelium-dependent vasodilation (8.6+/-1.2 versus 9.4+/-1.3%; NS). In contrast, intraarterial infusion of norepinephrine of similar duration as mental stress did not inhibit FMD. CONCLUSIONS: Mental stress induces prolonged endothelial dysfunction, which is prevented by selective endothelin-A receptor antagonism. This represents a novel and important link between mental stress and atherosclerotic vascular disease.
Keywords
Adult Arteriosclerosis/etiology Endothelium, Vascular/*physiopathology Humans Kinetics Nitroglycerin/pharmacology Peptides, Cyclic/pharmacology Radial Artery/physiopathology/ultrasonography Receptor, Endothelin A Receptors, Endothelin/antagonists & inhibitors/*physiology Risk Factors Stress, Psychological/complications/*physiopathology Vasodilation Vasodilator Agents/pharmacology
Pubmed
Web of science
Create date
17/01/2008 16:38
Last modification date
20/08/2019 13:14
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