Trends in cervical squamous cell carcinoma incidence in 13 European countries: changing risk and the effects of screening

Details

Serval ID
serval:BIB_2FC59194A661
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Trends in cervical squamous cell carcinoma incidence in 13 European countries: changing risk and the effects of screening
Journal
Cancer Epidemiology, Biomarkers and Prevention
Author(s)
Bray Freddie, Loos Anja H., McCarron Peter, Weiderpass Elizabete, Arbyn Mark, Møller Henrik, Hakama Matti, Levi Fabio
Working group(s)
Parkin D. Max
ISSN
1055-9965
Publication state
Published
Issued date
2005
Peer-reviewed
Oui
Volume
14
Number
3
Pages
677-686
Language
english
Notes
In acknowledgments: The following European cancer registries are participating investigators [...] Switzerland: [...] Registre neuchâtelois des tumeurs, Neuchâtel (Dr. Fabio Levi), Registre vaudois des tumeurs, Lausanne (Dr. Fabio Levi) [...] Réf. IUMSP: R 05/48 Mention de responsabiblité : / Bray F, Loos AH, McCarron P, Weiderpass E, Arbyn M, Moller H, et al. SAPHIRID:46586 --- Old url value: http://cebp.aacrjournals.org/cgi/content/abstract/14/3/677
Abstract
Despite there being sufficient evidence for the effectiveness of screening by cytology in preventing cancer of the cervix uteri, screening policies vary widely among European countries, and incidence is increasing in younger women. This study analyzes trends in squamous cell carcinoma (SCC) of the cervix uteri in 13 European countries to evaluate effectiveness of screening against a background of changing risk. Age-period-cohort models were fitted and period and cohort effects were estimated; these were considered as primarily indicative of screening interventions and changing etiology, respectively. A unique set of estimates was derived by fixing age slopes to one of several plausible age curves under the assumption that the relation between age and cervical cancer incidence is biologically determined. There were period-specific declines in cervical SCC in several countries, with the largest decreases seen in northern Europe. A pattern emerged across Europe of escalating risk in successive generations born after 1930. In the western European countries, a decrease followed by a stabilization of risk by cohort was accompanied by period-specific declines. In southern Europe, stable period, but increasing cohort trends, were observed. Substantial changes have occurred in cervical SCC incidence in Europe and well-organized screening programs have been highly effective in reducing the incidence of cervical SCC. Screening and changing sexual mores largely explain the changing period- and cohort-specific patterns, respectively. The increasing risk in recent cohorts is of obvious concern particularly in countries where no screening programs are in place. Further investigation of the effectiveness of opportunistic screening is warranted as is the observation of differing risk patterns in young cohorts in countries with relatively similar societal structures. [Authors]
Pubmed
Web of science
Open Access
Yes
Create date
05/03/2008 9:28
Last modification date
20/08/2019 13:14
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