Survival costs of reproduction in Drosophila.

Details

Serval ID
serval:BIB_2FB2D0A90B5A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Survival costs of reproduction in Drosophila.
Journal
Experimental Gerontology
Author(s)
Flatt T.
ISSN
1873-6815 (Electronic)
ISSN-L
0531-5565
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
46
Number
5
Pages
369-375
Language
english
Abstract
Reproduction shortens lifespan in practically all organisms examined so far, but the underlying mechanisms remain largely unknown to date. Here I review what evolutionary and molecular biologists have learned about such "costs of reproduction" in the fruit fly (Drosophila melanogaster) since Maynard Smith's (1958) seminal discovery that sterile mutants in D. subobscura live substantially longer than fertile wildtype flies. Together with observations from the nematode worm (Caenorhabditis elegans) and other organisms, the data from Drosophila suggest that there are at least four general principles that underlie trade-offs between reproduction and lifespan: (1) trade-offs between survival and reproduction are widespread; (2) the relationship between increased lifespan and decreased fecundity can be uncoupled under certain conditions; (3) while survival costs of reproduction might not necessarily be due to competitive resource allocation, we lack robust alternative explanations for their occurrence; and (4) physiological trade-offs between reproduction and longevity do not always translate into evolutionary genetic trade-offs. I conclude that - despite much recent progress - our current understanding of the proximate basis of survival costs of reproduction remains very limited; much future work on the genetics and physiology of such trade-offs will be required to uncover their mechanistic basis.
Keywords
Aging/physiology, Animals, Drosophila melanogaster/physiology, Longevity/physiology, Models, Animal, Reproduction/physiology
Pubmed
Web of science
Create date
28/01/2013 11:44
Last modification date
20/08/2019 13:14
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