The facilitatory effect of duloxetine combined with pelvic floor muscle training on the excitability of urethral sphincter motor neurons.

Details

Serval ID
serval:BIB_2FB0C11C53A4
Type
Article: article from journal or magazin.
Collection
Publications
Title
The facilitatory effect of duloxetine combined with pelvic floor muscle training on the excitability of urethral sphincter motor neurons.
Journal
International Urogynecology Journal and Pelvic Floor Dysfunction
Author(s)
Mehnert U., Boy S., Widmer-Simitovic S., Reitz A., Schurch B.
Publication state
Published
Issued date
2009
Volume
20
Number
6
Pages
659-666
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
INTRODUCTION AND HYPOTHESIS: Aim of this study was to investigate the excitability of sphincter motor neurons under the influence of pelvic floor muscle training (PFMT) and duloxetine. Due to their mechanisms of action, there might be a synergistic effect of duloxetine and PFMT in regard to the facilitation of spinal reflexes controlling urethral sphincter contractions and hence continence.
METHODS: In ten healthy female subjects, clitoral electric stimulation (CES) and transcranial magnetic stimulation (TMS) were used to determine individual motor thresholds for external urethral sphincter (EUS) contractions before and after PFMT, duloxetine, and PFMT + duloxetine.
RESULTS: PFMT and duloxetine alone significantly decreased the motor thresholds for EUS contractions during CES and TMS. However, the combined treatment reduced the motor threshold for EUS contractions significantly stronger compared to PFMT or duloxetine alone.
CONCLUSIONS: The results are suggestive for a synergistic facilitatory effect of PFMT and duloxetine on sphincter motor neuron activation.
Keywords
Adult, Combined Modality Therapy, Exercise Therapy, Female, Humans, Motor Neurons/drug effects, Muscle Contraction, Pelvic Floor/physiology, Serotonin Uptake Inhibitors/pharmacology, Serotonin Uptake Inhibitors/therapeutic use, Thiophenes/pharmacology, Thiophenes/therapeutic use, Urethra/drug effects, Urinary Incontinence, Stress/drug therapy, Urodynamics, Young Adult
Pubmed
Web of science
Create date
05/11/2014 12:12
Last modification date
20/08/2019 13:14
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