Primary follicular lymphoma of the small intestine: alpha4beta7 expression and immunoglobulin configuration suggest an origin from local antigen-experienced B cells.

Details

Serval ID
serval:BIB_2FA9643208CC
Type
Article: article from journal or magazin.
Collection
Publications
Title
Primary follicular lymphoma of the small intestine: alpha4beta7 expression and immunoglobulin configuration suggest an origin from local antigen-experienced B cells.
Journal
American Journal of Pathology
Author(s)
Bende R.J., Smit L.A., Bossenbroek J.G., Aarts W.M., Spaargaren M., de Leval L., Boeckxstaens G.E., Pals S.T., van Noesel C.J.
ISSN
0002-9440[print], 0002-9440[linking]
Publication state
Published
Issued date
2003
Volume
162
Number
1
Pages
105-113
Language
english
Abstract
Primary follicular lymphoma of the gastrointestinal tract (GI-FL) is a rare so far poorly studied entity. We analyzed four FL cases located in the small intestine and duodenum to gain insight in their pathogenesis and to find an explanation for their low tendency to disseminate outside the GI tract. GI-FLs resemble nodal FLs with respect to morphology and expression of typical GC markers such as CD10, CD38, and BCL-6. We established that the high levels of the anti-apoptosis protein BCL-2 in the tumor cells are in all cases due to a t(14;18) involving the immunoglobulin heavy chain and BCL-2 loci. Detailed immunoglobulin gene analyses on microdissected tissue samples further supported the GC-cell derivation: GI-FLs carry extensively mutated variable heavy-chain genes. The mutation patterns indicated that at some time point in development stringent antigen receptor-based selection processes must have occurred. Interestingly, three of four neoplasms expressed surface IgA, an immunoglobulin class typical of the mucosal immune system and seldom found in nodal FL. In contrast to nodal FLs, the GI-FLs expressed the alpha4beta7 integrin, an established mucosa-homing receptor also expressed by normal intestinal B and T lymphocytes and by low-grade mucosa-associated lymphoid tissue lymphomas. However, the chemokine receptor CXCR3, expressed on low-grade mucosa-associated lymphoid tissue lymphomas, was not detected on the GI-FLs or on nodal FLs. The combined data suggests that primary FL of the small intestine is a distinct entity that originates from local antigen-responsive B cells.
Keywords
Adult, Aged, Antigens/immunology, B-Lymphocytes/immunology, Base Sequence, Biopsy, Complementarity Determining Regions/genetics, DNA Mutational Analysis, Female, Humans, Immunoglobulin Heavy Chains/genetics, Immunoglobulin Variable Region/genetics, Integrins/biosynthesis, Intestinal Neoplasms/genetics, Intestinal Neoplasms/immunology, Intestine, Small/pathology, Lymphoma, Follicular/genetics, Lymphoma, Follicular/immunology, Male, Middle Aged, Molecular Sequence Data, Proto-Oncogene Proteins c-bcl-2/biosynthesis, Receptors, Lymphocyte Homing/genetics, Tumor Markers, Biological/biosynthesis
Pubmed
Create date
28/10/2010 10:32
Last modification date
20/08/2019 13:14
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