Pression pulsee locale et regression de l'hypertrophie parietale arterielle au cours du traitement antihypertenseur. Etude Celimene. Celiprolol Intima-Media Enalapril Efficacy. [Local pulse pressure and regression of arterial wall hypertrophy during antihypertensive treatment. CELIMENE study. The Celiprolol Intima-Media Enalapril Efficacy study]

Details

Serval ID
serval:BIB_2F6B500975CA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Pression pulsee locale et regression de l'hypertrophie parietale arterielle au cours du traitement antihypertenseur. Etude Celimene. Celiprolol Intima-Media Enalapril Efficacy. [Local pulse pressure and regression of arterial wall hypertrophy during antihypertensive treatment. CELIMENE study. The Celiprolol Intima-Media Enalapril Efficacy study]
Journal
Archives des Maladies du Coeur et des Vaisseaux
Author(s)
Boutouyrie  P., Bussy  C., Tropeano  A. I., Hayoz  D., Hengstler  J., Dartois  N., Laloux  B., Brunner  H., Laurent  S.
ISSN
0003-9683 (Print)
Publication state
Published
Issued date
08/2000
Volume
93
Number
8
Pages
911-5
Notes
Clinical Trial
Comparative Study
English Abstract
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Aug
Abstract
BACKGROUND: Local Pulse Pressure (PP) is an independent determinant of carotid artery wall thickness, stronger than mean BP. The present study was designed to assess whether a beta-adrenoceptor antagonist or an ACE inhibitor-based treatment was able to reduce carotid artery wall hypertrophy through the reduction in carotid PP rather than by lowering mean BP, and whether the influence of local PP reduction could also be detected at the site of a muscular artery, the radial artery. METHODS AND RESULTS: Ninety-eight essential hypertensive patients were randomised to 9 months of double-blind treatment with either celiprolol or enalapril. Arterial parameters were determined with high resolution echotracking systems. PP was measured locally with PP applanation tonometry, and independently of mean BP. After 9 month's treatment, mean BP, carotid PP and intima-media thickness (IMT) decreased significantly, with no difference between the tow groups. The reduction in carotid pression pulsee, but not in mean BP, was a major independent determinant of the reduction in carotid IMT. Radial artery IMT and PP decreased significantly with both treatments. However, the reduction in radial artery IMT was not related to the changes in radial artery PP. CONCLUSION: The regression of carotid artery wall hypertrophy during long-term antihypertensive treatment was dependent on the reduction in local PP rather than on the lowering of mean BP. The effect of PP lowering on IMT reduction was observed at the site of an elastic artery but not at the site of a muscular artery.
Keywords
Adrenergic beta-Antagonists/*therapeutic use Analysis of Variance Angiotensin-Converting Enzyme Inhibitors/*therapeutic use Antihypertensive Agents/*therapeutic use Blood Pressure/*drug effects Carotid Arteries/*drug effects/pathology/ultrasonography Celiprolol/therapeutic use Chi-Square Distribution Double-Blind Method Enalapril/therapeutic use Female Follow-Up Studies Heart Rate/drug effects Humans Hypertension/*drug therapy Hypertrophy Male Pulse Radial Artery/drug effects Regional Blood Flow/drug effects Regression Analysis Tunica Intima/drug effects Tunica Media/drug effects Vascular Resistance/drug effects
Pubmed
Web of science
Create date
17/01/2008 16:38
Last modification date
20/08/2019 13:13
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