Molecular organization of the HLA-SB region of the human major histocompatibility complex and evidence for two SB beta-chain genes.

Details

Serval ID
serval:BIB_2F4F0820178B
Type
Article: article from journal or magazin.
Collection
Publications
Title
Molecular organization of the HLA-SB region of the human major histocompatibility complex and evidence for two SB beta-chain genes.
Journal
Proceedings of the National Academy of Sciences of the United States of America
Author(s)
Gorski J., Rollini P., Long E., Mach B.
ISSN
0027-8424 (Print)
ISSN-L
0027-8424
Publication state
Published
Issued date
1984
Volume
81
Number
13
Pages
3934-3938
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
The class II products of the major histocompatibility complex, also called Ia antigens, are composed of two polypeptide chains, the alpha and beta chains, both encoded within the major histocompatibility complex. In man, the class II antigens can be divided into three biochemically distinct groups called HLA-DR, HLA-DC, and HLA-SB. Our isolation of cDNA clones for the polymorphic beta chain of HLA-DR and HLA-DC has allowed us to study the organization of the class II genes. Here we identify the HLA-SB beta-chain gene in recombinant clones from a cosmid library generated from a consanguineous homozygous B-cell line. The SB beta-chain gene is linked to the SB alpha-chain gene and the two genes are in opposite orientation. A second SB beta-chain gene, corresponding to a new SB beta II locus, has also been identified and cloned. The SB beta-chain genes show much less allelic restriction site polymorphism than the genes for the beta chains of HLA-DR or HLA-DC.
Keywords
Amino Acid Sequence, Base Sequence, Cloning, Molecular, DNA/analysis, DNA Restriction Enzymes, Genes, MHC Class II, HLA-DP Antigens, Histocompatibility Antigens Class II/analysis, Humans, Macromolecular Substances, Major Histocompatibility Complex, Nucleic Acid Hybridization, Plasmids
Pubmed
Web of science
Create date
11/11/2011 11:16
Last modification date
20/08/2019 13:13
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