Signaling lymphocyte activation molecule family in systemic lupus erythematosus.

Details

Serval ID
serval:BIB_2F4AE7A7E7B6
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Signaling lymphocyte activation molecule family in systemic lupus erythematosus.
Journal
Clinical immunology
Author(s)
Comte D., Karampetsou M.P., Humbel M., Tsokos G.C.
ISSN
1521-7035 (Electronic)
ISSN-L
1521-6616
Publication state
Published
Issued date
07/2019
Peer-reviewed
Oui
Volume
204
Pages
57-63
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease characterized by a breakdown in immune tolerance leading to the development of auto-reactive lymphocytes and autoantibodies. Recent findings have provided new insight on the role of the signaling lymphocytic activation molecule family (SLAMF) receptors, a group of nine co-regulatory molecules involved in the activation of hematopoietic cells, and their downstream protein SLAM-associated protein (SAP), into the pathogenesis of SLE. This review summarizes the current knowledge on SLAMF in human SLE immunopathogenesis, and the importance of SLAMF molecules as new therapeutic targets.
Keywords
Animals, Humans, Lupus Erythematosus, Systemic/immunology, Signaling Lymphocytic Activation Molecule Family/immunology
Pubmed
Web of science
Create date
26/11/2018 17:37
Last modification date
05/04/2020 5:20
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