Striatal function in normal aging: implications for Parkinson's disease.

Details

Serval ID
serval:BIB_2F28C4853404
Type
Article: article from journal or magazin.
Collection
Publications
Title
Striatal function in normal aging: implications for Parkinson's disease.
Journal
Annals of Neurology
Author(s)
Sawle G.V., Colebatch J.G., Shah A., Brooks D.J., Marsden C.D., Frackowiak R.S.
ISSN
0364-5134 (Print)
ISSN-L
0364-5134
Publication state
Published
Issued date
1990
Volume
28
Number
6
Pages
799-804
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Central to several current theories of the etiology of Parkinson's disease is the premise that the nigrostriatal dopaminergic system degenerates with normal aging. Much of the evidence for this assertion has come from postmortem neurochemical studies. We have used L-6-[18F] fluoro-Dopa and positron emission tomography in 26 healthy volunteers (age range, 27-76 years) to examine striatal and frontal cortical tracer uptake. Data have been analyzed by using a graphical approach to calculate an influx constant (Ki) for L-6-[18F]fluoro-Dopa uptake into the caudate, putamen, and medial frontal cortex of each subject. In the population studied, there was no decline in Ki with age for any of these structures. A series of physiological measurements made on the older subjects also showed few significant changes with age. The positron emission tomographic findings demonstrate preservation of nigrostriatal dopaminergic function in normal aging. The pathological process causing Parkinson's disease may operate closer to the time of presentation than has been suggested.
Keywords
Adult, Aged, Aging/physiology, Caudate Nucleus/metabolism, Corpus Striatum/physiology, Corpus Striatum/radionuclide imaging, Dihydroxyphenylalanine/metabolism, Female, Fluorine Radioisotopes/diagnostic use, Frontal Lobe/metabolism, Humans, Male, Middle Aged, Parkinson Disease/etiology, Putamen/metabolism, Reference Values, Tomography, Emission-Computed
Pubmed
Web of science
Create date
06/10/2011 20:00
Last modification date
20/08/2019 13:13
Usage data