Interferon regulatory factor 7 is associated with Epstein-Barr virus-transformed central nervous system lymphoma and has oncogenic properties1

Details

Serval ID
serval:BIB_2F22EC8545E0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Interferon regulatory factor 7 is associated with Epstein-Barr virus-transformed central nervous system lymphoma and has oncogenic properties1
Journal
Journal of Virology
Author(s)
Zhang  L., Zhang  J., Lambert  Q., Der  C. J., Del  V. L., Miklossy  J., Khalili  K., Zhou  Y., Pagano  J. S.
ISSN
0022-538X (Print)
Publication state
Published
Issued date
2004
Volume
78
Number
23
Pages
12987-12995
Notes
PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S
Abstract
Interferon regulatory factor 7 (IRF-7) is implicated in the regulation of Epstein-Barr virus (EBV) latency. EBV transforms primary B cells, and the major EBV oncoprotein, latent membrane protein 1 (LMP-1), is required for the process. LMP-1 both induces the expression of IRF-7 and activates the IRF-7 protein by phosphorylation and nuclear translocation. Here we report that the expression of IRF-7 is increased in EBV-immortalized B lymphocytes compared with that in primary B cells. IRF-7 was phosphorylated and predominantly localized in the nucleus in the immortalized cells. The expression of IRF-7 was detected in 19 of 27 specimens of primary lymphomas of the human central nervous system by immunohistochemical analysis. The association between LMP-1 and IRF-7 was statistically highly significant for these specimens. An appreciable amount of the IRF-7 expressed in lymphoma cells was localized in the nucleus. Furthermore, IRF-7 promoted the anchorage-independent growth of NIH 3T3 cells. LMP-1 and IRF-7 showed additive effects on the growth transformation of NIH 3T3 cells. IRF-7-expressing NIH 3T3 cells formed tumors in athymic mice. Thus, IRF-7 has oncogenic properties and, along with LMP-1, may mediate or potentiate the EBV transformation process in the pathogenesis of EBV-associated lymphomas
Keywords
3T3 Cells/Adult/Aged/Aged,80 and over/analysis/Animals/B-Lymphocytes/Brain Neoplasms/Cell Division/Cell Transformation,Viral/Cells/Central Nervous System/DNA-Binding Proteins/Female/Herpesvirus 4,Human/Humans/Interferon Regulatory Factor-7/Lymphocytes/Lymphoma/Male/Mice/Mice,Nude/Middle Aged/Nih 3T3 Cells/pathogenicity/Phosphorylation/physiology/Proteins/Research/Science/Viral Matrix Proteins/virology
Pubmed
Web of science
Open Access
Yes
Create date
29/01/2008 18:33
Last modification date
20/08/2019 13:13
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