Ambulatory Blood Pressure in Relation to Plasma and Urinary Manganese.

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Version: Author's accepted manuscript
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Serval ID
serval:BIB_2F14E41018C7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Ambulatory Blood Pressure in Relation to Plasma and Urinary Manganese.
Journal
Hypertension
Author(s)
Zhang ZY, Carmeli C., Ponte B., Pruijm M., Ackermann D., Ehret G., Guessous I., Petrović D., Pechère-Bertschi A., Vogt B., Martin PY, Burnier M., Lenglet S., Augsburger M., Thomas A., Bochud M.
ISSN
1524-4563 (Electronic)
ISSN-L
0194-911X
Publication state
Published
Issued date
04/2020
Peer-reviewed
Oui
Volume
75
Number
4
Pages
1133-1139
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The association of blood pressure (BP) with manganese-an essential trace element required for human health-remains poorly studied. In 734 randomly recruited Swiss participants (mean age, 47.5 years; 51.4% women), we related ambulatory BP to 2 biomarkers, plasma manganese (pMn) and the urinary manganese (uMn) excretion. To allow for diurnal variation, we assessed BP and uMn over 24 hours and during wakefulness and sleep, using split urine samples. Twenty-four-hour, daytime, and nighttime systolic/diastolic BPs averaged 119.8/78.1, 123.8/81.2, and 107.0/68.3 mm Hg; the corresponding median uMn were 199.5, 83.0, and 51.5 μmol and median pMn, 0.52 μg/L. In analyses dichotomized by the median of the biomarkers, greater pMn was associated with higher 24-hour systolic/diastolic BP (+4.1/+2.3 mm Hg; P≤0.0003), greater daytime uMn with lower daytime BP (-3.5/-1.9 mm Hg; P≤0.0067), and greater nighttime uMn with higher nighttime BP (+2.9/+1.2 mm Hg; P≤0.046). In multivariable-adjusted analyses, significance (P≤0.030) was retained for the positive association of 24-hour and daytime diastolic BP with pMn and for systolic BP in relation to uMn at night. The association sizes for a 2-fold increment in the biomarkers amounting to 0.77 mm Hg (95% CI, 0.08-1.47 mm Hg), 0.97 (CI, 0.20-1.76) and 1.33 (CI, 0.20-2.50 mm Hg), respectively. In conclusion, there were positive associations between diastolic BP and pMn over 24 hours and during daytime and between systolic BP and uMn at night.
Keywords
blood pressure, environmental exposure, humans, hypertension, manganese
Pubmed
Web of science
Open Access
Yes
Create date
03/03/2020 9:21
Last modification date
04/02/2021 6:25
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