Assessing the Relationship between the Baseline Value of a Continuous Variable and Subsequent Change over Time

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Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
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Title
Assessing the Relationship between the Baseline Value of a Continuous Variable and Subsequent Change over Time
Journal
Frontiers in Public Health
Author(s)
Chiolero Arnaud, Paradis Gilles, Rich Benjamin, Hanley James
Publication state
Published
Issued date
2013
Volume
1
Number
29
Pages
1-8
Language
english
Abstract
Analyzing the relationship between the baseline value and subsequent change of a continuous variable is a frequent matter of inquiry in cohort studies. These analyses are surprisingly complex, particularly if only two waves of data are available. It is unclear for non-biostatisticians where the complexity of this analysis lies and which statistical method is adequate.With the help of simulated longitudinal data of body mass index in children,we review statistical methods for the analysis of the association between the baseline value and subsequent change, assuming linear growth with time. Key issues in such analyses are mathematical coupling, measurement error, variability of change between individuals, and regression to the mean. Ideally, it is better to rely on multiple repeated measurements at different times and a linear random effects model is a standard approach if more than two waves of data are available. If only two waves of data are available, our simulations show that Blomqvist's method - which consists in adjusting for measurement error variance the estimated regression coefficient of observed change on baseline value - provides accurate estimates. The adequacy of the methods to assess the relationship between the baseline value and subsequent change depends on the number of data waves, the availability of information on measurement error, and the variability of change between individuals.
Pubmed
Open Access
Yes
Create date
02/11/2011 12:18
Last modification date
20/08/2019 13:13
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