La gynécomastie sous anti-androgènes: un mal inéluctable? La radiothérapie: une solution simple et efficace! [Antiandrogen gynecomastia: an inescapable harm? Radiotherapy: a simple and efficient solution!]

Details

Serval ID
serval:BIB_2EFB598119D4
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
La gynécomastie sous anti-androgènes: un mal inéluctable? La radiothérapie: une solution simple et efficace! [Antiandrogen gynecomastia: an inescapable harm? Radiotherapy: a simple and efficient solution!]
Journal
Revue medicale de la Suisse romande
Author(s)
Couke P.A., Jichliski P., Matzinger O., Ozsahin M., Bulling S.M., Zouhair A.
ISSN
0035-3655 (Print)
ISSN-L
0035-3655
Publication state
Published
Issued date
01/2004
Peer-reviewed
Oui
Volume
124
Number
1
Pages
51-54
Language
french
Notes
Publication types: English Abstract ; Journal Article ; Review
Publication Status: ppublish
Abstract
Anti-androgen induced gynecomastia, resulting from a treatment induced imbalance between oestrogens and androgens, is a frequently encountered side effect in the hormonal treatment of patients with prostatic cancer. One might expect to face an increase in the overall incidence of this side effect in the next-coming years as randomized trials clearly point to the evidence of the therapeutic benefit of anti-androgenic treatment for this prostatic cancer. Gynecomastia is often accompanied by mastodynia and does hamper quality of life. Surgery should be considered for established irreversible gynecomastia characterized by hyalinization and extensive fibrosis. However, radiotherapy is the treatment of choice for gynecomastia at it's early stage, or could eventually be considered as a prophylactic treatment in high risk patients. It is a safe and extremely well tolerated treatment resulting in a high degree of therapeutic success with a demonstrated effect on quality of life as reported in randomized trials. To date no medical treatment is proven effective nor devoid from deleterious effects and licenced for this indication.

Keywords
Androgen Antagonists/adverse effects, Gynecomastia/chemically induced, Gynecomastia/drug therapy, Gynecomastia/radiotherapy, Gynecomastia/surgery, Humans, Male
Pubmed
Create date
24/01/2008 17:20
Last modification date
20/08/2019 13:13
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