Intérêt des faibles doses de rt-PA dans les syndromes inflammatoires et hémorragiques du segment antérieur: étude clinique et revue de la littérature [Treatment of anterior segment fibrinous reactions and hemorrhage with intracameral low dose rt-PA: clinical study and review of the literature].

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State: Public
Version: Final published version
Serval ID
serval:BIB_2EDC36E2E0FE
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Intérêt des faibles doses de rt-PA dans les syndromes inflammatoires et hémorragiques du segment antérieur: étude clinique et revue de la littérature [Treatment of anterior segment fibrinous reactions and hemorrhage with intracameral low dose rt-PA: clinical study and review of the literature].
Journal
Journal Français D'ophtalmologie
Author(s)
Le Rouic J.F., Behar-Cohen F., Nghiem M.H., Renard G., Chauvaud D.
ISSN
0181-5512 (Print)
ISSN-L
0181-5512
Publication state
Published
Issued date
2000
Peer-reviewed
Oui
Volume
23
Number
10
Pages
977-983
Language
french
Notes
Publication types: Clinical Trial ; English Abstract ; Journal Article ; Review Publication Status: ppublish
Abstract
PURPOSE: to evaluate the efficacy and the safety of low dose intraocular tissue plasminogen activator (rt-PA) in the treatment of traumatic hyphema and postoperative fibrinous membrane.
METHODS: Six microg to 10 microg of rt-PA was injected into the anterior chamber to treat severe fibrinous postoperative membranes and total traumatic hyphemae.
RESULTS: Thirteen eyes of 13 patients were treated. Four cases of traumatic hyphema and 9 cases of fibrinous membranes were included. Complete fibrinolysis within 24 hours was observed in 4 cases (30.8%). A partial success was noted in 7 eyes (53.8%). No beneficial effect was observed in two cases of traumatic hyphema associated with intravitreal hemorrhage after penetrating trauma. No side effect attributable to rt-PA occurred.
CONCLUSION: Low dose intraocular rt-PA appears to be safe and effective in the treatment of postoperative fibrinous membrane and endocular hemorrhage limited to the anterior chamber.
Keywords
Adolescent, Adult, Aged, Child, Eye Injuries/drug therapy, Female, Fibrin/secretion, Fibrinolytic Agents/therapeutic use, Humans, Hyphema/drug therapy, Inflammation/drug therapy, Inflammation/etiology, Male, Middle Aged, Ophthalmologic Surgical Procedures, Postoperative Complications/drug therapy, Recombinant Proteins/therapeutic use, Tissue Plasminogen Activator/therapeutic use
Pubmed
Web of science
Create date
10/04/2014 9:14
Last modification date
20/08/2019 13:13
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