Pityriasis rosea is not associated with human herpesvirus 7

Details

Serval ID
serval:BIB_2EC5D2174E63
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Pityriasis rosea is not associated with human herpesvirus 7
Journal
Archives of Dermatology
Author(s)
Kempf  W., Adams  V., Kleinhans  M., Burg  G., Panizzon  R. G., Campadelli-Fiume  G., Nestle  F. O.
ISSN
0003-987X (Print)
Publication state
Published
Issued date
09/1999
Volume
135
Number
9
Pages
1070-2
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep
Abstract
OBJECTIVE: To examine the proposed association between pityriasis rosea and human herpesvirus 7 (HHV-7). DESIGN: A retrospective cross-sectional survey. SETTING: University medical center in Switzerland. PATIENTS: Thirteen patients with pityriasis rosea and 14 persons with normal skin (control subjects). MAIN OUTCOME MEASURES: Detection of HHV-7-specific DNA sequences and antigen (85-kd phosphoprotein [pp85]) by nested polymerase chain reaction and immunohistochemical analysis, respectively. RESULTS: Human herpesvirus 7 DNA sequences and expression of the HHV-7-specific immunodominant pp85 antigen were found in 1 (8%) of 13 lesional skin biopsy specimens of pityriasis rosea. The prevalence of HHV-7 DNA sequences and antigens is even slightly lower in lesional skin of patients with pityriasis rosea than in clinically and morphologically normal skin of 14 control persons, in 2 of whom (14%) HHV-7 DNA sequences and antigens could be detected. CONCLUSION: The low detection rate of HHV-7 DNA sequences and antigens argues strongly against a causative role for HHV-7 in the pathogenesis of pityriasis rosea.
Keywords
Adolescent Adult Antigens, Viral/analysis Biopsy Cross-Sectional Studies DNA, Viral/analysis *Herpesvirus 7, Human/genetics/immunology Humans Middle Aged Pityriasis Rosea/*virology Retrospective Studies
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 16:54
Last modification date
20/08/2019 13:13
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