Paraneoplastic Cerebellar Ataxia Can Affect Prognosis in High-Grade Serous Ovarian Cancer: A Case Report.

Details

Serval ID
serval:BIB_2EBF9B7A049D
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Paraneoplastic Cerebellar Ataxia Can Affect Prognosis in High-Grade Serous Ovarian Cancer: A Case Report.
Journal
Case reports in oncology
Author(s)
Liapi A., Sarivalasis A.
ISSN
1662-6575 (Print)
ISSN-L
1662-6575
Publication state
Published
Issued date
2020
Peer-reviewed
Oui
Volume
13
Number
2
Pages
1006-1012
Language
english
Notes
Publication types: Case Reports
Publication Status: epublish
Abstract
The reported case is a 61-year-old woman, admitted for gradual onset of gait disturbances and dysphonia. The serum immunological panel revealed anti-Yo autoantibodies, suggestive of a paraneoplastic syndrome (PNS). A PET-CT revealed a suspicious left ovarian mass with retroperitoneal nodal involvement, and the histological assessment of surgical samples confirmed a FIGO IIIC high-grade serous ovarian cancer (HGSOC). Deemed inoperable at first, the patient was treated by carboplatin and paclitaxel chemotherapy, after which she refused surgical debulking. At the end of her systemic treatment, the patient only experienced a transient improvement of the cerebellar ataxia. Despite the suboptimal oncological treatment, the patient still presents stable disease and is free of progression 7 years from her diagnosis. This case study illustrates the favorable effect of PNS occurrence on oncological outcome in a patient with advanced HGSOC. The absence of recurrence despite the presence of residual disease after the systemic treatment is unusual and could be related to the PNS.
Keywords
Ovarian cancer, Paraneoplastic syndrome, Prognosis
Pubmed
Web of science
Open Access
Yes
Create date
09/10/2020 13:59
Last modification date
26/11/2020 6:24
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