Social adversity and epigenetic aging: a multi-cohort study on socioeconomic differences in peripheral blood DNA methylation.

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State: Public
Version: Final published version
Serval ID
serval:BIB_2E8C9389F21D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Social adversity and epigenetic aging: a multi-cohort study on socioeconomic differences in peripheral blood DNA methylation.
Journal
Scientific reports
Author(s)
Fiorito G., Polidoro S., Dugué P.A., Kivimaki M., Ponzi E., Matullo G., Guarrera S., Assumma M.B., Georgiadis P., Kyrtopoulos S.A., Krogh V., Palli D., Panico S., Sacerdote C., Tumino R., Chadeau-Hyam M., Stringhini S., Severi G., Hodge A.M., Giles G.G., Marioni R., Karlsson Linnér R., O'Halloran A.M., Kenny R.A., Layte R., Baglietto L., Robinson O., McCrory C., Milne R.L., Vineis P.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Publication state
Published
Issued date
24/11/2017
Peer-reviewed
Oui
Volume
7
Number
1
Pages
16266
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Low socioeconomic status (SES) is associated with earlier onset of age-related chronic conditions and reduced life-expectancy, but the underlying biomolecular mechanisms remain unclear. Evidence of DNA-methylation differences by SES suggests a possible association of SES with epigenetic age acceleration (AA). We investigated the association of SES with AA in more than 5,000 individuals belonging to three independent prospective cohorts from Italy, Australia, and Ireland. Low SES was associated with greater AA (β = 0.99 years; 95% CI 0.39,1.59; p = 0.002; comparing extreme categories). The results were consistent across different SES indicators. The associations were only partially modulated by the unhealthy lifestyle habits of individuals with lower SES. Individuals who experienced life-course SES improvement had intermediate AA compared to extreme SES categories, suggesting reversibility of the effect and supporting the relative importance of the early childhood social environment. Socioeconomic adversity is associated with accelerated epigenetic aging, implicating biomolecular mechanisms that may link SES to age-related diseases and longevity.
Keywords
Aged, Aging/genetics, Cohort Studies, DNA Methylation/genetics, Epigenesis, Genetic/genetics, Female, Humans, Male, Middle Aged, Socioeconomic Factors
Pubmed
Web of science
Open Access
Yes
Create date
30/11/2017 18:55
Last modification date
20/08/2019 13:13
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