Local photodynamic therapy reduces tissue hyperplasia in an experimental restenosis model.

Details

Serval ID
serval:BIB_2E838BEF6D0B
Type
Article: article from journal or magazin.
Collection
Publications
Title
Local photodynamic therapy reduces tissue hyperplasia in an experimental restenosis model.
Journal
Photochemistry and Photobiology
Author(s)
Gonschior P., Gerheuser F., Fleuchaus M., Huehns T.Y., Goetz A.E., Welsch U., Sroka R., Dellian M., Lehr H.A., Höfling B.
ISSN
0031-8655 (Print)
ISSN-L
0031-8655
Publication state
Published
Issued date
1996
Volume
64
Number
5
Pages
758-763
Language
english
Abstract
Local photodynamic therapy may have potential in preventing myointimal hyperplasia after angioplasty. In this study, the effect of photodynamic therapy was evaluated in an experimental model of restenosis. Standardized unidirectional arterial injury with a directional atherectomy catheter was performed in porcine arteries. Animals were randomly allocated to four groups: group 1, unidirectional injury only; group 2, injury followed by local delivery of photosensitizer; group 3, injury followed by local exposure to monochromatic light; and group 4, where injury was followed by local drug delivery of photosensitizer and subsequent exposure to light (photodynamic therapy). Seven, 14 or 21 days after treatment, all experimental vessels were excised, fixed and processed for histology. An inflammatory and myoproliferative response was observed after injury in vessels from groups 1, 2 and 3. In group 4, after injury followed by photodynamic therapy, the myoproliferative response was significantly reduced. Thus, in this study, tissue hyperplasia after unidirectional injury was effectively suppressed by photodynamic therapy.
Keywords
Animals, Arterial Occlusive Diseases/drug therapy, Arterial Occlusive Diseases/pathology, Disease Models, Animal, Hyperplasia, Photochemotherapy/methods, Photosensitizing Agents/pharmacology, Swine, Tunica Intima/drug effects, Tunica Intima/pathology
Pubmed
Create date
25/11/2011 19:31
Last modification date
20/08/2019 13:13
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