Occurrence of skin manifestations in patients of the Swiss Inflammatory Bowel Disease Cohort Study.

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Version: Final published version
Serval ID
serval:BIB_2E72015BEF07
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Occurrence of skin manifestations in patients of the Swiss Inflammatory Bowel Disease Cohort Study.
Journal
PloS one
Author(s)
Roth N., Biedermann L., Fournier N., Butter M., Vavricka S.R., Navarini A.A., Rogler G., Scharl M.
Working group(s)
Swiss IBD Cohort Study Group
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Publication state
Published
Issued date
2019
Peer-reviewed
Oui
Volume
14
Number
1
Pages
e0210436
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Extraintestinal cutaneous manifestations of IBD represent a severe disease complication and an early and accurate treatment might positively influence the disease course. Using the patient collective of the Swiss IBD Cohort Study (SIBDCS), we analysed epidemiological as well as clinical factors being associated with the onset of pyoderma gangrenosum, erythema nodosum and aphthous ulcers in IBD patients.
We included 3266 SIBDCs patients, 1840 with Crohn's disease (CD) and 1426 with ulcerative colitis (UC) or IBD unclassified (IBDU) and analysed the association of cutaneous manifestations with age, age at diagnosis time, type of disease, gender, family history, HLA-allotype, smoking, intestinal disease activity, therapy and other extraintestinal manifestations (EIM).
354 CD patients and 136 UC/IBDU patients presented with skin manifestations at any time during their disease course. In both, CD and UC, female gender and younger age at IBD diagnosis were significantly associated with extraintestinal skin manifestations. For CD, we also detected a positive family history as associated factor. As an indicator of more intensive intestinal disease activity, patients with cutaneous manifestations of IBD needed more frequently therapy with antibiotics, steroids, immunomodulators and anti-TNF. Multivariate analysis revealed female gender, younger age at diagnosis and presence of other extraintestinal manifestations as factors being associated with skin EIM in IBD patients and anti-TNF as well as immunomodulatory treatment in CD patients.
Our results suggest that young females with a positive family history of IBD might be at increased risk for the onset of skin manifestations and require a careful screening for such complications.
Pubmed
Web of science
Open Access
Yes
Create date
15/02/2019 15:15
Last modification date
20/08/2019 13:13
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