Redefining diuretics use in hypertension: why select a thiazide-like diuretic?

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Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_2E55704A82DF
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Redefining diuretics use in hypertension: why select a thiazide-like diuretic?
Journal
Journal of hypertension
Author(s)
Burnier M., Bakris G., Williams B.
ISSN
1473-5598 (Electronic)
ISSN-L
0263-6352
Publication state
Published
Issued date
08/2019
Peer-reviewed
Oui
Volume
37
Number
8
Pages
1574-1586
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
: Diuretics are listed in hypertension guidelines as one of three equally weighted first-line treatment options. In order to differentiate between antihypertensives, a lot of discussion has been directed at side effect profiles and as a result, has created a perhaps disproportionate fear of the metabolic effects that can be associated with diuretics. Data, however, show that the risk of a clinically meaningful change in laboratory parameters is very low, whereas the benefits of volume control and natriuresis are high and the reductions in morbidity and mortality are clinically significant. Moreover, as clinically significant differences in safety and efficacy profiles exist among diuretics, several international guidelines have started making a distinction between thiazides (hydrochlorothiazide) and thiazide-like (chlorthalidone, indapamide) diuretics; and some of them now recommend longer acting thiazide-like diuretics. In time, pending more data, chlorthalidone and indapamide may need to be subdivided further into separate classifications.
Keywords
Diuretics/adverse effects, Diuretics/therapeutic use, Humans, Hypertension/drug therapy, Practice Guidelines as Topic, Thiazides/adverse effects, Thiazides/therapeutic use
Pubmed
Web of science
Open Access
Yes
Create date
10/04/2019 16:23
Last modification date
15/01/2021 7:08
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