Surgical glues: are they really adhesive?

Details

Ressource 1Download: serval:BIB_2E40AF9D48EF.P001 (278.12 [Ko])
State: Public
Version: author
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_2E40AF9D48EF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Surgical glues: are they really adhesive?
Journal
European Journal of Cardio-thoracic Surgery
Author(s)
Perrin B.R., Dupeux M., Tozzi P., Delay D., Gersbach P., von Segesser L.K.
ISSN
1873-734X[electronic], 1010-7940[linking]
Publication state
Published
Issued date
2009
Volume
36
Number
6
Pages
967-972
Language
english
Abstract
OBJECTIVE: The aim of this study is to create a standard test to approve the efficacy of a surgical sealant. An industrial test, the bulge-and-blister test, which is very convenient for measuring adhesion energy, is applied to the surgical field to quantify adhesion of bioadhesives. METHODS: Samples were composed of two circular layers of equine pericardium glued by the surgical sealant studied. The sample was fixed to a support with an industrial glue. The support and the bottom layer were perforated in the centre to allow injection of pressurised water. Water was progressively introduced through the hole in the support and the bottom layer to create a blister with constant radius, increasing height and internal pressure during this first step. At a critical pressure, delamination started, the radius and height of the blister increased and the pressure decreased. At this point, the adhesion energy could be determined. The experimental parameters were measured with a pressure sensor and an optical profilometry device for deflection. RESULTS: Adhesion testing was carried out in eight paired equine pericardium samples bonded with a Dermabond cyanoacrylate glue. The average value of the practical adhesion energy is 2.3 Jm(-2) with a standard deviation of 1.5 Jm(-2). CONCLUSION: Application of the bulge-and-blister test to the surgical field was achieved and allowed a quantification of adhesion of a surgical glue. Such information is essential to compare the different surgical glues presently available. The study of the impact of bonding conditions such as pressure, hygrometry or setting conditions will provide a better understanding of the characteristics of adhesion in the surgical field.
Keywords
Adhesiveness, Animals, Cyanoacrylates/chemistry, Cyanoacrylates/pharmacology, Horses, Materials Testing/instrumentation, Materials Testing/methods, Pericardium/drug effects, Pressure, Stress, Mechanical, Tissue Adhesives/chemistry, Tissue Adhesives/pharmacology
Pubmed
Web of science
Open Access
Yes
Create date
30/03/2010 13:49
Last modification date
25/09/2019 6:08
Usage data