Targeting thrombus stabilization: protection against thrombosis without bleeding?
Details
Serval ID
serval:BIB_2E3D05DE16D2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Targeting thrombus stabilization: protection against thrombosis without bleeding?
Journal
Drug Discovery Today: Disease Models
ISSN
1740-6757
Publication state
Published
Issued date
2004
Volume
1
Number
3
Pages
279-287
Language
english
Abstract
Platelets initiate arrest of bleeding at sites of vascular injury but also trigger inopportune arterial thrombosis, which causes heart attacks and strokes. After formation of a single platelet monolayer at the site of injury, additional platelets are recruited into the growing hemostatic plug. Without further stabilization, the platelet plug disaggregates. Its stabilization is insured by perpetuation of platelet activation. Drugs designed to prevent thrombus stabilization rather than inhibition of its formation are currently not available. Targeting perpetuation of platelet activation reveals that it is possible to block thrombosis without eliciting bleeding.
Create date
04/02/2008 15:54
Last modification date
20/08/2019 13:12