Detection rate of FNA cytology in medullary thyroid carcinoma: a meta-analysis.

Details

Serval ID
serval:BIB_2E005C3E3E5A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Detection rate of FNA cytology in medullary thyroid carcinoma: a meta-analysis.
Journal
Clinical Endocrinology
Author(s)
Trimboli P., Treglia G., Guidobaldi L., Romanelli F., Nigri G., Valabrega S., Sadeghi R., Crescenzi A., Faquin W.C., Bongiovanni M., Giovanella L.
ISSN
1365-2265 (Electronic)
ISSN-L
0300-0664
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
82
Number
2
Pages
280-285
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
BACKGROUND: The early detection of medullary thyroid carcinoma (MTC) can improve patient prognosis, because histological stage and patient age at diagnosis are highly relevant prognostic factors. As a consequence, delay in the diagnosis and/or incomplete surgical treatment should correlate with a poorer prognosis for patients. Few papers have evaluated the specific capability of fine-needle aspiration cytology (FNAC) to detect MTC, and small series have been reported. This study conducts a meta-analysis of published data on the diagnostic performance of FNAC in MTC to provide more robust estimates.
RESEARCH DESIGN AND METHODS: A comprehensive computer literature search of the PubMed/MEDLINE, Embase and Scopus databases was conducted by searching for the terms 'medullary thyroid' AND 'cytology', 'FNA', 'FNAB', 'FNAC', 'fine needle' or 'fine-needle'. The search was updated until 21 March 2014, and no language restrictions were used.
RESULTS: Fifteen relevant studies and 641 MTC lesions that had undergone FNAC were included. The detection rate (DR) of FNAC in patients with MTC (diagnosed as 'MTC' or 'suspicious for MTC') on a per lesion-based analysis ranged from 12·5% to 88·2%, with a pooled estimate of 56·4% (95% CI: 52·6-60·1%). The included studies were statistically heterogeneous in their estimates of DR (I-square >50%). Egger's regression intercept for DR pooling was 0·03 (95% CI: -3·1 to 3·2, P = 0·9). The study that reported the largest MTC series had a DR of 45%. Data on immunohistochemistry for calcitonin in diagnosing MTC were inconsistent for the meta-analysis.
CONCLUSIONS: The presented meta-analysis demonstrates that FNAC is able to detect approximately one-half of MTC lesions. These findings suggest that other techniques may be needed in combination with FNAC to diagnose MTC and avoid false negative results.
Pubmed
Web of science
Create date
21/01/2015 9:17
Last modification date
20/08/2019 13:12
Usage data