Intrauterine growth restriction: clinical consequences on health and disease at adulthood.

Details

Serval ID
serval:BIB_2DE0D5EF4BDE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Intrauterine growth restriction: clinical consequences on health and disease at adulthood.
Journal
Reproductive toxicology
Author(s)
Armengaud J.B., Yzydorczyk C., Siddeek B., Peyter A.C., Simeoni U.
ISSN
1873-1708 (Electronic)
ISSN-L
0890-6238
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Intrauterine growth restriction (IUGR) affects 10 to 15% of all pregnancies worldwide. IUGR may result from maternal, placental or fetal origin. Maternal malnutrition before and during pregnancy represents the most prevalent non-genetic or placental cause. IUGR reflects an abnormal adaptive fetal growth in a deleterious environment. Individuals born after IUGR are more susceptible to develop diseases related to subsequent stressors through a lifetime. Animal models help to decipher the underlying causes of dysregulated pathways and molecular modifications conditioning health and disease in adult offspring born after IUGR. The aim of this review is to summarize current knowledge on long term consequences of IUGR, integrating animal models and human studies for a better care of IUGR-born individuals in a life course perspective.
Keywords
-programming, DOHaD, IUGR, life course, programming
Pubmed
Open Access
Yes
Create date
19/10/2020 13:38
Last modification date
21/01/2021 6:26
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