Emerging landscape of oncogenic signatures across human cancers.

Details

Serval ID
serval:BIB_2DDFA83C84AB
Type
Article: article from journal or magazin.
Collection
Publications
Title
Emerging landscape of oncogenic signatures across human cancers.
Journal
Nature genetics
Author(s)
Ciriello G., Miller M.L., Aksoy B.A., Senbabaoglu Y., Schultz N., Sander C.
ISSN
1546-1718 (Electronic)
ISSN-L
1061-4036
Publication state
Published
Issued date
10/2013
Peer-reviewed
Oui
Volume
45
Number
10
Pages
1127-1133
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Cancer therapy is challenged by the diversity of molecular implementations of oncogenic processes and by the resulting variation in therapeutic responses. Projects such as The Cancer Genome Atlas (TCGA) provide molecular tumor maps in unprecedented detail. The interpretation of these maps remains a major challenge. Here we distilled thousands of genetic and epigenetic features altered in cancers to ∼500 selected functional events (SFEs). Using this simplified description, we derived a hierarchical classification of 3,299 TCGA tumors from 12 cancer types. The top classes are dominated by either mutations (M class) or copy number changes (C class). This distinction is clearest at the extremes of genomic instability, indicating the presence of different oncogenic processes. The full hierarchy shows functional event patterns characteristic of multiple cross-tissue groups of tumors, termed oncogenic signature classes. Targetable functional events in a tumor class are suggestive of class-specific combination therapy. These results may assist in the definition of clinical trials to match actionable oncogenic signatures with personalized therapies.
Keywords
DNA Copy Number Variations, Epigenesis, Genetic, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Molecular Sequence Annotation, Mutation, Neoplasms/genetics, Neoplasms/therapy, Oncogenes, Sequence Analysis, DNA
Pubmed
Web of science
Open Access
Yes
Create date
06/07/2018 11:02
Last modification date
20/08/2019 13:12
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