Cohort profile: the Swiss Mother and Child HIV Cohort Study (MoCHiV).

Details

Ressource 1Download: Paioni et al 2024.pdf (1143.63 [Ko])
State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_2DDE7997EB96
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cohort profile: the Swiss Mother and Child HIV Cohort Study (MoCHiV).
Journal
BMJ open
Author(s)
Paioni P., Capaul M., Brunner A., Traytel A., Aebi-Popp K., Crisinel P.A., Duppenthaler A., Günthard H., Martinez De Tejada B., Kottanattu L., Stöckle M., Rauch A., Wagner N., Hösli I., Rudin C., Scherrer A., Kusejko K., Kahlert C.R.
Working group(s)
Swiss HIV Cohort Study (SHCS) and the Swiss Mother and Child HIV Cohort Study (MoCHiV)
Contributor(s)
Abela I., Aebi-Popp K., Anagnostopoulos A., Battegay M., Baumann M., Bernasconi E., Braun D.L., Bucher H.C., Calmy A., Cavassini M., Ciuffi A., Crisinel P.A., Darling K., Duppenthaler A., Dollenmaier G., Egger M., Elzi L., Fehr J., Fellay J., Francini K., Furrer H., Fux C.A., Günthard H.F., Hachfeld A., Haerry D., Hasse B., Hirsch H.H., Hoffmann M., Hösli I., Huber M., Jackson-Perry D., Kahlert C.R., Kaiser L., Kapfhammer E., Keiser O., Klimkait T., Kohns M., Kottanattu L., Kouyos R.D., Kovari H., Kusejko K., Labhardt N., Martinez de Tejada B., Marzolini C., Metzner K.J., Müller N., Nemeth J., Nicca D., Notter J., Paioni P., Pantaleo G., Perreau M., Ch P., Rauch A., Salazar-Vizcaya L., Schmid P., Speck R., Stöckle M., Tarr P., Thanh Lecompte M., Trkola A., Wagner N., Wandeler G., Weisser M., Yerly S., Böni J., Cheseaux J.J., Francioli P., Hirschel B., Kind C., Ledergerber B., Nadal D., Rickenbach M., Rudin C., Schüpbach J., Siegrist C.A.
ISSN
2044-6055 (Electronic)
ISSN-L
2044-6055
Publication state
Published
Issued date
23/09/2024
Peer-reviewed
Oui
Volume
14
Number
9
Pages
e086543
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Observational Study
Publication Status: epublish
Abstract
Prospective, multicentric observational cohort study in Switzerland investigating measures to prevent mother-to-child transmission in pregnant women with HIV (WWH) and assessing health and development of their exposed children as well as of children with HIV (CWH) in general.
Between January 1986 and December 2022, a total of 1446 mother-child pairs were enrolled. During the same period, the study also registered 187 CWH and 521 HIV-exposed but uninfected children (HEU), for whom detailed maternal information was not available. Consequently, the cohort comprises a total of 2154 children.
During these 37 years, research by the Swiss Mother and Child HIV Cohort Study (MoCHiV) and its international collaborators has strongly influenced the prevention of vertical transmission of HIV (eg, introduction and discontinuation of elective caesarean section, neonatal postexposure prophylaxis and breastfeeding). Contributions have also been made to the management of diagnostics (eg, p24 antigen assay) and the effects of antiretroviral treatment (eg, prematurity, growth) in HEU and CWH.
Most children present within the cohort are now HEU, highlighting the need to investigate other vertically transmitted pathogens such as hepatitis B and C viruses, cytomegalovirus or Treponema pallidum. In addition, analyses are planned on the longitudinal health status of CWH (eg, resistance and prolonged exposure to antiretroviral therapy), on social aspects including stigma in CWH and HEU, and on interventions to further optimise antenatal and postpartum care in WWH.
Keywords
Humans, Infectious Disease Transmission, Vertical/prevention & control, Female, Switzerland/epidemiology, HIV Infections/prevention & control, HIV Infections/transmission, HIV Infections/epidemiology, Pregnancy, Pregnancy Complications, Infectious/epidemiology, Prospective Studies, Infant, Newborn, Infant, Adult, Child, Male, Child, Preschool, Breast Feeding/statistics & numerical data, Cohort Studies, HIV & AIDS, Pregnant Women
Pubmed
Open Access
Yes
Create date
27/09/2024 15:49
Last modification date
11/10/2024 20:18
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