Gonadal steroids, salt-sensitivity and renal function

Details

Serval ID
serval:BIB_2D536454CD78
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Gonadal steroids, salt-sensitivity and renal function
Journal
Current Opinion in Nephrology and Hypertension
Author(s)
Pechere-Bertschi  A., Burnier  M.
ISSN
1062-4821 (Print)
Publication state
Published
Issued date
01/2007
Volume
16
Number
1
Pages
16-21
Notes
Journal Article
Review --- Old month value: Jan
Abstract
PURPOSE OF REVIEW: The aim of this article is to discuss the impact of male and female sex hormones on renal function and to develop the concept that salt-sensitivity of renal function behaves independently of the systemic blood pressure response to salt and may contribute to renal sex-specific differences. RECENT FINDINGS: Men exhibit a more rapid age-related decline in renal function than women and some renal diseases are clearly sex dependent. Recent studies have shown that gonadal steroids have an important influence on sodium handling and renal hemodynamics that may offer a key for understanding the sexual dimorphism of the renal function. It has been found that androgens increase proximal sodium reabsorption and intraglomerular pressure by modulating afferent and efferent arteriolar tonus via angiotensin II, endothelin and oxidative stress. In contrast, female sex hormones lead to a renal vasodilation and decrease filtration fraction. SUMMARY: Some newly discovered mechanisms triggering the salt-sensitivity of the renal function and the interaction between gonadal steroids and components of the renin cascade may play an important role in the dimorphism of renal response to salt.
Keywords
Androgens/physiology Estrogens/physiology Female Gonadal Steroid Hormones/*physiology Humans Kidney/metabolism/*physiology Male Progesterone/physiology Renin-Angiotensin System/physiology Sex Characteristics Sodium/*metabolism
Pubmed
Web of science
Create date
25/01/2008 12:55
Last modification date
20/08/2019 13:12
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