Studies off the opiate control of prolactin, GH and TSH

Details

Serval ID
serval:BIB_2D4F57891F4A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Studies off the opiate control of prolactin, GH and TSH
Journal
Clinical Endocrinology
Author(s)
Grossman  A., Stubbs  W. A., Gaillard  R. C., Delitala  G., Rees  L. H., Besser  G. M.
ISSN
0300-0664 (Print)
Publication state
Published
Issued date
04/1981
Volume
14
Number
4
Pages
381-6
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Apr
Abstract
Opiate peptides are known to influence the secretion of several anterior pituitary hormones under basal conditions. Further studies on prolactin, GH and TSH have therefore been performed in normal subjects, under basal and stimulated conditions, using an opiate agonist and antagonist. Sixteen mg naloxone had no effect on the basal release of prolactin or GH, but lowered TSH. An infusion of the met-enkephalin analogue DAMME (1 mg) increased GH, and produced an exaggerated response of both prolactin and TSH to 200 micrograms TRH i.v. The peak responses of both prolactin and GH to hypoglycaemia were unaffected by pretreatment with either low-dose (0.4 mg) or high-dose (25 mg) naloxone, or DAMME (0.25 mg). These results suggest that opiate peptides are unlikely to play a major role in the tonic or hypoglycaemia-stimulated release of prolactin and GH, although they may be of importance in the control of TSH.
Keywords
Adolescent Adult Blood Glucose/metabolism D-Ala(2),MePhe(4),Met(0)-ol-enkephalin Endorphins/*pharmacology Enkephalins/*pharmacology Female Growth Hormone/*secretion Hormones/*pharmacology Humans Insulin/diagnostic use Male Naloxone/*pharmacology Prolactin/*secretion Thyrotropin/*secretion
Pubmed
Web of science
Create date
15/02/2008 16:58
Last modification date
20/08/2019 13:12
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