Pneumopathie organisee cryptogenique.

Details

Serval ID
serval:BIB_2D4DD65644A7
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Pneumopathie organisee cryptogenique.
Journal
Revue de Pneumologie Clinique
Author(s)
Lazor  R.
ISSN
0761-8417
Publication state
Published
Issued date
06/2005
Peer-reviewed
Oui
Volume
61
Number
3
Pages
193-202
Notes
English Abstract
Journal Article
Review
Abstract
Organising Pneumonia (formerly called Bronchiolitis Obliterans with Organising Pneumonia) is a particular form of inflammatory and fibroproliferative lung disease. Its idiopathic form called Cryptogenic Organising Pneumonia, was recently defined by an ATS/ERS consensus conference. The disease onset is subacute with cough, dyspnea, fever, asthenia, weight loss, crackles, and elevation of biological inflammatory markers. Bronchoalveolar lavage reveals a mixed alveolitis with elevated lymphocyte, neutrophil, and eosinophil counts. Chest imaging usually shows multifocal alveolar opacities predominating in the subpleural regions, often with a migratory pattern. Lung biopsy reveals budding connective tissue filling the distal airspaces. Diagnosis is established by combining clinical, radiological and histological criteria. Similarities with other disease processes can lead to delayed or erroneous diagnosis. Most patients respond well to corticosteroid therapy. Relapses are frequent but can generally be controlled with moderate doses of prednisone and do not worsen the prognosis. The therapeutic strategy aims at reducing the steroid doses while maintaining an optimal disease control.
Keywords
Biopsy Bronchiolitis Obliterans Organizing Pneumonia/*diagnosis/drug therapy/pathology/radiography Bronchoalveolar Lavage Fluid Diagnosis, Differential Glucocorticoids/therapeutic use Humans Prognosis Pulmonary Alveoli/*pathology
Pubmed
Create date
19/12/2008 11:58
Last modification date
20/08/2019 13:12
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