Cutting edge: an essential role for Notch-1 in the development of both thymus-independent and -dependent T cells in the gut.

Details

Serval ID
serval:BIB_2D3B96FEE679
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cutting edge: an essential role for Notch-1 in the development of both thymus-independent and -dependent T cells in the gut.
Journal
Journal of immunology
Author(s)
Wilson A., Ferrero I., MacDonald H.R., Radtke F.
ISSN
0022-1767
Publication state
Published
Issued date
2000
Peer-reviewed
Oui
Volume
165
Number
10
Pages
5397-5400
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Whereas most T cells arise in the thymus, a distinct lineage of extrathymically derived T cells is present in the gut mucosa. The developmental origin of extrathymic T cells is poorly understood. We show here that Notch-1, a transmembrane receptor involved in T cell fate specification of bipotential T/B precursors in the thymus, is absolutely required for the development of extrathymic (as well as thymus-derived) mature T cells in the intestinal epithelium. In the absence of Notch-1, CD117(+) T cell precursors are relatively more abundant in the gut than the thymus, whereas immature B cells accumulate in the thymus but not the gut. Collectively, these data demonstrate that Notch-1 is essential for both thymic and extrathymic T cell fate specification and further suggest that bipotential T/B precursors that do not receive a Notch-1 signal adopt a B cell fate in the thymus but become developmentally arrested in the gut.
Keywords
Animals, Antigens, T-Independent/immunology, Bone Marrow Transplantation, CD8-Positive T-Lymphocytes/cytology, CD8-Positive T-Lymphocytes/immunology, Cell Differentiation/genetics, Cell Differentiation/immunology, Cell Lineage/genetics, Cell Lineage/immunology, Dimerization, Intestinal Mucosa/cytology, Intestinal Mucosa/immunology, Membrane Proteins/deficiency, Membrane Proteins/genetics, Mice, Mice, Inbred C57BL, Mice, Transgenic, Proto-Oncogene Proteins c-kit/biosynthesis, Radiation Chimera/immunology, Receptor, Notch1, Receptors, Cell Surface, Signal Transduction/genetics, Signal Transduction/immunology, T-Lymphocyte Subsets/cytology, T-Lymphocyte Subsets/immunology, Thymus Gland/cytology, Thymus Gland/immunology, Transcription Factors
Pubmed
Web of science
Create date
28/01/2008 11:39
Last modification date
20/08/2019 13:12
Usage data