Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus.

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State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_2D26D1AA952C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus.
Journal
Cold Spring Harbor Perspectives In Biology
Author(s)
Toni N., Schinder A.F.
ISSN
1943-0264 (Electronic)
ISSN-L
1943-0264
Publication state
Published
Issued date
2015
Volume
8
Number
1
Pages
a018903
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
The adult hippocampus generates functional dentate granule cells (GCs) that release glutamate onto target cells in the hilus and cornus ammonis (CA)3 region, and receive glutamatergic and γ-aminobutyric acid (GABA)ergic inputs that tightly control their spiking activity. The slow and sequential development of their excitatory and inhibitory inputs makes them particularly relevant for information processing. Although they are still immature, new neurons are recruited by afferent activity and display increased excitability, enhanced activity-dependent plasticity of their input and output connections, and a high rate of synaptogenesis. Once fully mature, new GCs show all the hallmarks of neurons generated during development. In this review, we focus on how developing neurons remodel the adult dentate gyrus and discuss key aspects that illustrate the potential of neurogenesis as a mechanism for circuit plasticity and function.
Keywords
Dentate Gyrus/cytology, Dentate Gyrus/growth & development, Hippocampus/cytology, Hippocampus/growth & development, Models, Biological, Nerve Net, Neurogenesis, Neuronal Plasticity, Neurons/cytology, Synapses/physiology
Pubmed
Web of science
Open Access
Yes
Create date
29/01/2016 7:20
Last modification date
20/08/2019 13:12
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