Copeptin, a stable peptide derived from the vasopressin precursor, correlates with the individual stress level.

Details

Serval ID
serval:BIB_2D1B0976A376
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Copeptin, a stable peptide derived from the vasopressin precursor, correlates with the individual stress level.
Journal
Neuro Endocrinology Letters
Author(s)
Katan M., Morgenthaler N., Widmer I., Puder J.J., König C., Müller B., Christ-Crain M.
ISSN
0172-780X
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
29
Number
3
Pages
341-6
Language
english
Notes
Publication types: Journal Article - Publication Status: ppublish
Abstract
BACKGROUND: During stress, vasopressin is a potent synergistic factor of CRH as a hypothalamic stimulator of the HPA axis. The measurements of CRH and vasopressin levels are cumbersome because of their instability and short half-life. Copeptin is a more stable peptide stoichiometrically released from the same precursor molecule. The aim of our study was to compare copeptin and cortisol levels in different stress situations. METHODS: Three groups of patients with increasing stress levels were investigated: a) healthy controls without apparent stress (n=20), b) hospitalized medical patients with moderate stress (n=25) and c) surgical patients 30 minutes after extubation, with maximal stress (n=29). In all patients we assessed cortisol and copeptin levels. Copeptin levels were measured with a new sandwich immunoassay. RESULTS: Cortisol levels in controls were (median, IQ range, 486 [397-588] nmol/L), not significantly different as compared to medical patients (438 [371-612] nmol/L, p=0.69). Cortisol levels in surgical patients after extubation were higher (744 [645-1062] nmol/L p<0.01 vs controls and medical patients). Copeptin levels in controls were 4.3 [3.2-5.5] pmol/L, which was lower as compared to medical patients (17.5 [6.4-24.1], p<0.001) and surgical patients after extubation (67.5 [37.8-110.0] pmol/L, p<0.001). The correlation between copeptin levels and cortisol was r=0.46, p<0.001. CONCLUSION: Copeptin is a novel marker of the individual stress level. It more subtly mirrors moderate stress as compared to cortisol values.
Keywords
Adrenocorticotropic Hormone, Adult, Biological Markers, Body Mass Index, Cohort Studies, Female, Glycopeptides, Humans, Hydrocortisone, Hypothalamus, Male, Middle Aged, Sex Characteristics, Stress, Psychological, Vasopressins
Pubmed
Web of science
Create date
13/03/2009 11:38
Last modification date
20/08/2019 13:12
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