Preeclampsia-like symptoms induced in mice by fetoplacental expression of STOX1 are reversed by aspirin treatment.

Details

Serval ID
serval:BIB_2D18CE034D54
Type
Article: article from journal or magazin.
Collection
Publications
Title
Preeclampsia-like symptoms induced in mice by fetoplacental expression of STOX1 are reversed by aspirin treatment.
Journal
Hypertension
Author(s)
Doridot L., Passet B., Méhats C., Rigourd V., Barbaux S., Ducat A., Mondon F., Vilotte M., Castille J., Breuiller-Fouché M., Daniel N., le Provost F., Bauchet A.L., Baudrie V., Hertig A., Buffat C., Simeoni U., Germain G., Vilotte J.L., Vaiman D.
ISSN
1524-4563 (Electronic)
ISSN-L
0194-911X
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
61
Number
3
Pages
662-668
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
Preeclampsia (PE) is a common human-specific pregnancy disorder defined by hypertension and proteinuria during gestation and responsible for maternal and fetal morbimortality. STOX1, encoding a transcription factor, was the first gene associated with PE as identified by positional cloning approaches. Its overexpression in choriocarcinoma cells mimics the transcriptional consequences of PE in the human placenta. Here, we created transgenic mouse strains overexpressing human STOX1. Wild-type female mice crossed with transgenic male mice reproduce accurately the symptoms of severe PE: gestational hypertension, proteinuria, and elevated plasma levels of soluble fms-like tyrosine kinase 1 and soluble endoglin. Placental and kidney histology were altered. Symptoms were prevented or alleviated by aspirin treatment. STOX1-overexpressing mice constitute a unique model for studying PE, allow testing therapeutic approaches, and assessing the long-term effects of the preeclamptic syndrome.
Keywords
Animals, Anti-Inflammatory Agents, Non-Steroidal/therapeutic use, Antihypertensive Agents/therapeutic use, Aspirin/therapeutic use, Carrier Proteins/adverse effects, Carrier Proteins/biosynthesis, Disease Models, Animal, Female, Humans, Intracellular Signaling Peptides and Proteins/blood, Kidney/pathology, Male, Mice, Mice, Transgenic, Placenta/metabolism, Placenta/pathology, Pre-Eclampsia/drug therapy, Pre-Eclampsia/etiology, Pregnancy, Severity of Illness Index, Vascular Endothelial Growth Factor Receptor-1/blood
Pubmed
Web of science
Open Access
Yes
Create date
22/02/2015 9:12
Last modification date
20/08/2019 13:12
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