Early postoperative decrease of albumin is an independent predictor of major complications after oncological esophagectomy: A multicenter study.

Details

Serval ID
serval:BIB_2D10617D801B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Early postoperative decrease of albumin is an independent predictor of major complications after oncological esophagectomy: A multicenter study.
Journal
Journal of surgical oncology
Author(s)
Labgaa I., Mantziari S., Genety M., Elliott J.A., Kamiya S., Kalff M.C., Winiker M., Pasquier J., Allemann P., Messier M., van Berge Henegouwen M.I., Nilsson M., Reynolds J.V., Piessen G., Hübner M., Demartines N., Schäfer M.
ISSN
1096-9098 (Electronic)
ISSN-L
0022-4790
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Serum albumin perioperative decrease (∆Alb) may reflect the magnitude of the physiological stress induced by surgery. Studies highlighted its value to predict adverse postoperative outcomes, but data in esophageal surgery are scant. This study aimed to investigate the role of ∆Alb to predict major complications after esophagectomy for cancer.
Multicenter retrospective study conducted in five high-volume centers, including consecutive patients undergoing an esophagectomy for cancer between 2006 and 2017. Patients were randomly assigned to a training (n = 696) and a validation (n = 350) cohort. Albumin decrease was calculated on postoperative day 1 and defined as ΔAlb. The primary endpoint was major complications according to Clavien classification.
In the training cohort, esophagectomy induced a rapid drop of albumin. Cut-off of ΔAlb was established at 11 g/L and allowed to distinguish patients with adverse outcomes. On multivariable analysis, ΔAlb was identified as an independent predictor of major complications (OR, 1.06; 95% CI, 1.01-1.11; p = .014). Higher BMI and laparoscopy were associated with lower ΔAlb. Analysis of the validation cohort provided consistent findings.
ΔAlb appeared as a promising biomarker after oncological esophagectomy, allowing prediction of potential adverse outcomes.
Keywords
Surgery, Oncology, General Medicine, biomarker, cancer, esophagus, surgical oncology
Pubmed
Web of science
Create date
07/12/2020 15:39
Last modification date
23/12/2020 6:24
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