A localization method for the measurement of fast relaxing C-13 NMR signals in humans at high magnetic fields

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Serval ID
serval:BIB_2CD476A707AF
Type
Article: article from journal or magazin.
Collection
Publications
Title
A localization method for the measurement of fast relaxing C-13 NMR signals in humans at high magnetic fields
Journal
Applied Magnetic Resonance
Author(s)
Oz G., Henry P.G., Tkac I., Gruetter R.
ISSN
0937-9347
Publication state
Published
Issued date
2005
Volume
29
Number
1
Pages
159-169
Language
english
Abstract
Nuclear magnetic resonance (NMR) signals with short T-1 and T-2, such as the C-13 signal of glycogen, are difficult to localize in three dimensions without major signal loss. A pulse sequence that accomplishes the spatial localization of H-1-decoupled C-13 NMR signals on a whole-body scanner within the Food and Drug Administration guidelines for specific absorption rates was designed. The method uses an optimized three-dimensional outer volume suppression scheme combined with one-dimensional image-selected in vivo spectroscopy and surface coil detection. The localization performance of the sequence was validated at 4 T with double chambered phantoms and C-13 magnetic resonance imaging. Localized C-13 spectra were acquired from human brain and muscle.
Keywords
human brain, resonance-spectroscopy, 4 tesla, carbohydrate-metabolism, glycogen, relaxation, mrs
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29/04/2013 9:41
Last modification date
20/08/2019 13:11
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