Clinical Indications and Compassionate Use of Phage Therapy: Personal Experience and Literature Review with a Focus on Osteoarticular Infections.

Details

Ressource 1Download: 30597868_BIB_2CC6E5747A60.pdf (290.60 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_2CC6E5747A60
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Clinical Indications and Compassionate Use of Phage Therapy: Personal Experience and Literature Review with a Focus on Osteoarticular Infections.
Journal
Viruses
Author(s)
Patey O., McCallin S., Mazure H., Liddle M., Smithyman A., Dublanchet A.
ISSN
1999-4915 (Electronic)
ISSN-L
1999-4915
Publication state
Published
Issued date
28/12/2018
Peer-reviewed
Oui
Volume
11
Number
1
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
The history of phage therapy started with its first clinical application in 1919 and continues its development to this day. Phages continue to lack any market approval in Western medicine as a recognized drug, but are increasingly used as an experimental therapy for the compassionate treatment of patients experiencing antibiotic failure. The few formal experimental phage clinical trials that have been completed to date have produced inconclusive results on the efficacy of phage therapy, which contradicts the many successful treatment outcomes observed in historical accounts and recent individual case reports. It would therefore be wise to identify why such a discordance exists between trials and compassionate use in order to better develop future phage treatment and clinical applications. The multitude of observations reported over the years in the literature constitutes an invaluable experience, and we add to this by presenting a number of cases of patients treated compassionately with phages throughout the past decade with a focus on osteoarticular infections. Additionally, an abundance of scientific literature into phage-related areas is transforming our knowledge base, creating a greater understanding that should be applied for future clinical applications. Due to the increasing number of treatment failures anticipatedfrom the perspective of a possible post-antibiotic era, we believe that the introduction of bacteriophages into the therapeutic arsenal seems a scientifically sound and eminently practicable consideration today as a substitute or adjuvant to antibiotic therapy.
Keywords
Anti-Bacterial Agents/therapeutic use, Arthritis, Infectious/microbiology, Arthritis, Infectious/therapy, Bacteriophages/physiology, Compassionate Use Trials, France, Humans, Phage Therapy, antibiotic resistance, antibiotic therapy, bacterial infection, bacteriophage, cases report, phage therapy
Pubmed
Web of science
Open Access
Yes
Create date
23/01/2019 10:47
Last modification date
20/08/2019 13:11
Usage data