Baseline knee adduction and flexion moments during walking are both associated with 5 year cartilage changes in patients with medial knee osteoarthritis.

Details

Serval ID
serval:BIB_2CB21A681855
Type
Article: article from journal or magazin.
Collection
Publications
Title
Baseline knee adduction and flexion moments during walking are both associated with 5 year cartilage changes in patients with medial knee osteoarthritis.
Journal
Osteoarthritis and cartilage
Author(s)
Chehab E.F., Favre J., Erhart-Hledik J.C., Andriacchi T.P.
ISSN
1522-9653 (Electronic)
ISSN-L
1063-4584
Publication state
Published
Issued date
11/2014
Peer-reviewed
Oui
Volume
22
Number
11
Pages
1833-1839
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
Publication Status: ppublish
Abstract
To test the hypothesis that knee cartilage changes over 5 years are associated with baseline peak knee adduction moment (KAM) and peak knee flexion moment (KFM) during early stance.
Baseline KAM and KFM were measured in sixteen subjects with medial knee osteoarthritis (OA). Regional changes in cartilage thickness and changes in medial-to-lateral thickness ratio were quantified using magnetic resonance imaging (MRI) at baseline and again after 5 years. Multiple regression was used to determine whether baseline measures of KAM and KFM were associated with cartilage changes over 5 years. Associations with baseline pain score, Kellgren-Lawrence (KL) grade, walking speed, age, gender, and body mass index (BMI) were tested one-by-one in the presence of KAM and KFM.
Changes over 5 years in femoral medial-to-lateral thickness ratio were associated with baseline KAM, KFM, and pain score (R(2) = 0.60, P = 0.010), and most significantly with KAM (R(2) = 0.33, P = 0.019). Changes in tibial medial-to-lateral thickness ratio were associated with baseline KAM, KFM, and walking speed (R(2) = 0.49, P = 0.039), with KFM driving this association (R(2) = 0.40, P = 0.009). Changes in medial tibial thickness were associated with baseline KAM, KFM, and walking speed (R(2) = 0.49, P = 0.041); KFM also drove this association (R(2) = 0.42, P = 0.006).
The findings that the KAM has a greater influence on femoral cartilage change and the KFM has a greater influence on tibial cartilage change provide new insight into the tibiofemoral variations in cartilage changes associated with walking kinetics. These results suggest that both KAM and KFM should be considered when designing disease interventions as well as when assessing the risk for OA progression.

Keywords
Aged, 80 and over, Cartilage, Articular/pathology, Disease Progression, Female, Follow-Up Studies, Humans, Knee Joint/pathology, Knee Joint/physiopathology, Magnetic Resonance Imaging/methods, Male, Osteoarthritis, Knee/pathology, Osteoarthritis, Knee/physiopathology, Range of Motion, Articular/physiology, Retrospective Studies, Time Factors, Walking/physiology, Ambulatory mechanics, Cartilage thickness, Disease progression, Gait, Kinetics, MRI
Pubmed
Web of science
Open Access
Yes
Create date
22/11/2017 18:26
Last modification date
20/08/2019 13:11
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